Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CKS1B | P61024 | 1/20 | 0.50 |
| ▸ | SKP1 | P63208 | 1/20 | 0.50 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.50 |
| ▸ | LSS | P48449 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | IDE | P14735 | 1/20 | 0.43 |
| ▸ | GBA1 | P04062 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | TP53 | P04637 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lithium Ion SCHEMBL31706628 | 1.00 | CKS1B (0.50) | CKS1BSKP1SKP2LSSALDH1A1 | |
| Lithium Ion SCHEMBL31705464 | 0.89 | LSS (0.41) | CKS1BSKP1SKP2LSSALDH1A1 | |
| Lithium Ion SCHEMBL31704621 | 0.89 | LSS (0.41) | CKS1BSKP1SKP2LSSALDH1A1 | |
| SCHEMBL31706098 | 0.87 | CKS1B (0.55) | CKS1BSKP1SKP2LSSALDH1A1 | |
| SCHEMBL31705550 | 0.82 | CKS1B (0.48) | CKS1BSKP1SKP2LSSALDH1A1 | |
| SCHEMBL31705275 | 0.82 | CKS1B (0.48) | CKS1BSKP1SKP2LSSALDH1A1 | |
| Lithium Ion SCHEMBL31706490 | 0.80 | HTR2B (0.38) | CKS1BSKP1SKP2ALDH1A1TDP1 | |
| Lithium Ion SCHEMBL31704920 | 0.80 | HTR2B (0.38) | CKS1BSKP1SKP2ALDH1A1TDP1 | |
| SCHEMBL31705724 | 0.80 | CKS1B (0.50) | CKS1BSKP1SKP2ALDH1A1GBA1 | |
| SCHEMBL31704520 | 0.80 | CKS1B (0.50) | CKS1BSKP1SKP2ALDH1A1GBA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025215110-A1 | NEW AMIDE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USES AS SOS1 INHIBITORS | LES LABORATOIRES SERVIER (FR) | 2025-10-16 | — | — | WO | disclosed |