Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.38 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | PDE2A | O00408 | 1/20 | 0.37 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.37 |
| ▸ | CKS1B | P61024 | 1/20 | 0.37 |
| ▸ | SKP1 | P63208 | 1/20 | 0.37 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.36 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lithium Ion SCHEMBL31706490 | 1.00 | HTR2B (0.38) | HTR2BALDH1A1CHEK1PDCD1CD274 | |
| SCHEMBL31705731 | 0.87 | HTR2B (0.42) | HTR2BALDH1A1CHEK1PDCD1CD274 | |
| SCHEMBL31705552 | 0.82 | MEN1 (0.41) | HTR2BALDH1A1CHEK1PDCD1CD274 | |
| Lithium Ion SCHEMBL31706628 | 0.80 | CKS1B (0.50) | ALDH1A1SMN1; SMN2NPC1TP53MAPT | |
| Lithium Ion SCHEMBL31705926 | 0.80 | CKS1B (0.50) | ALDH1A1SMN1; SMN2NPC1TP53MAPT | |
| Lithium Ion SCHEMBL31704937 | 0.74 | TLR9 (0.46) | HTR2BALDH1A1IDETLR9TLR8 | |
| Lithium Ion SCHEMBL31706661 | 0.74 | TLR9 (0.46) | HTR2BALDH1A1IDETLR9TLR8 | |
| SCHEMBL15755669 | 0.72 | HSD11B1 (0.51) | HTR2BALDH1A1SMN1; SMN2NPC1TP53 | |
| SCHEMBL23299633 | 0.70 | JAK1 (0.60) | — | |
| Lithium Ion SCHEMBL31704621 | 0.69 | LSS (0.41) | ALDH1A1SMN1; SMN2MAPTCKS1BSKP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025215110-A1 | NEW AMIDE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USES AS SOS1 INHIBITORS | LES LABORATOIRES SERVIER (FR) | 2025-10-16 | — | — | WO | disclosed |