Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.49 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 2/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | MMP1 | P03956 | 2/20 | 0.43 |
| ▸ | MMP2 | P08253 | 2/20 | 0.43 |
| ▸ | MMP9 | P14780 | 2/20 | 0.43 |
| ▸ | RECQL | P46063 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3170642 | 1.00 | KMT2A (0.49) | KMT2AMEN1MAPTNLRP3PIM2 | |
| SCHEMBL3163623 | 0.93 | PIM2 (0.44) | KMT2AMEN1MAPTNLRP3PIM2 | |
| SCHEMBL3163636 | 0.93 | PIM2 (0.44) | KMT2AMEN1MAPTNLRP3PIM2 | |
| SCHEMBL3171042 | 0.93 | PIM2 (0.54) | KMT2AMAPTPIM2CYP1A2ALDH1A1 | |
| SCHEMBL3171072 | 0.93 | PIM2 (0.54) | KMT2AMAPTPIM2CYP1A2ALDH1A1 | |
| SCHEMBL3163340 | 0.89 | SMN1; SMN2 (0.51) | KMT2AMEN1MAPTNLRP3PIM2 | |
| SCHEMBL3163351 | 0.89 | SMN1; SMN2 (0.51) | KMT2AMEN1MAPTNLRP3PIM2 | |
| SCHEMBL3164980 | 0.87 | CYP1A2 (0.43) | MAPTNLRP3PIM2CYP1A2CYP2C19 | |
| SCHEMBL3164995 | 0.87 | CYP1A2 (0.43) | MAPTNLRP3PIM2CYP1A2CYP2C19 | |
| SCHEMBL3169453 | 0.87 | CYP1A2 (0.47) | KMT2AMEN1MAPTPIM2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1465631-B1 | PYRIMIDINE A2B SELECTIVE ANTAGONIST COMPOUNDS, THEIR SYNTHESIS AND USE | OSI PHARM INC (US) | 2010-02-24 | — | — | EP | disclosed |