Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | PYGL | P06737 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3163351 | 1.00 | SMN1; SMN2 (0.51) | SMN1; SMN2ALDH1A1LMNAPKMHTT | |
| SCHEMBL3170960 | 0.91 | LMNA (0.53) | SMN1; SMN2ALDH1A1LMNAPKMHTT | |
| SCHEMBL3170956 | 0.91 | LMNA (0.53) | SMN1; SMN2ALDH1A1LMNAPKMHTT | |
| SCHEMBL3170642 | 0.89 | KMT2A (0.49) | SMN1; SMN2ALDH1A1LMNANPC1RAB9A | |
| SCHEMBL3170630 | 0.89 | KMT2A (0.49) | SMN1; SMN2ALDH1A1LMNANPC1RAB9A | |
| SCHEMBL3161992 | 0.88 | ALDH1A1 (0.50) | SMN1; SMN2ALDH1A1LMNAPKMHTT | |
| SCHEMBL3161981 | 0.88 | ALDH1A1 (0.50) | SMN1; SMN2ALDH1A1LMNAPKMHTT | |
| SCHEMBL3168246 | 0.84 | ADORA3 (0.40) | SMN1; SMN2CYP1A2MAPTNLRP3ADORA3 | |
| SCHEMBL3168238 | 0.84 | ADORA3 (0.40) | SMN1; SMN2CYP1A2MAPTNLRP3ADORA3 | |
| SCHEMBL3163636 | 0.83 | PIM2 (0.44) | ALDH1A1LMNACYP1A2MAPTNLRP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1465631-B1 | PYRIMIDINE A2B SELECTIVE ANTAGONIST COMPOUNDS, THEIR SYNTHESIS AND USE | OSI PHARM INC (US) | 2010-02-24 | — | — | EP | disclosed |