Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR9 | Q9NR96 | 6/20 | 0.43 |
| ▸ | TLR8 | Q9NR97 | 6/20 | 0.43 |
| ▸ | TLR7 | Q9NYK1 | 6/20 | 0.43 |
| ▸ | MAP3K12 | Q12852 | 10/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lithium Ion SCHEMBL31705410 | 1.00 | TLR9 (0.43) | TLR9TLR8TLR7MAP3K12CSF1R | |
| Lithium Ion SCHEMBL31705021 | 0.93 | MAP3K12 (0.39) | TLR9TLR8TLR7MAP3K12CSF1R | |
| SCHEMBL31706609 | 0.88 | TLR9 (0.45) | TLR9TLR8TLR7MAP3K12CSF1R | |
| Lithium Ion SCHEMBL31704797 | 0.86 | MAP3K12 (0.41) | MAP3K12OPRM1 | |
| SCHEMBL31706475 | 0.84 | TLR9 (0.47) | TLR9TLR8TLR7MAP3K12CSF1R | |
| Lithium Ion SCHEMBL31706750 | 0.83 | TLR9 (0.43) | TLR9TLR8TLR7 | |
| Lithium Ion SCHEMBL31706258 | 0.83 | TLR9 (0.43) | TLR9TLR8TLR7 | |
| Lithium Ion SCHEMBL21633065 | 0.81 | LNPEP (0.37) | CSF1R | |
| SCHEMBL31705108 | 0.78 | TLR9 (0.42) | TLR9TLR8TLR7MAP3K12OPRM1 | |
| Lithium Ion SCHEMBL31706661 | 0.78 | TLR9 (0.46) | TLR9TLR8TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025215110-A1 | NEW AMIDE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USES AS SOS1 INHIBITORS | LES LABORATOIRES SERVIER (FR) | 2025-10-16 | — | — | WO | disclosed |