Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.70 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.70 |
| ▸ | HIF1A | Q16665 | 9/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.56 |
| ▸ | PGR | P06401 | 5/20 | 0.56 |
| ▸ | NR3C1 | P04150 | 5/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.56 |
| ▸ | AR | P10275 | 2/20 | 0.56 |
| ▸ | SERPINA6 | P08185 | 2/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.56 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.56 |
| ▸ | TNF | P01375 | 1/20 | 0.56 |
| ▸ | IL6 | P05231 | 1/20 | 0.56 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.56 |
| ▸ | GLUL | P15104 | 1/20 | 0.56 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.56 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 6/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3170728 | 1.00 | KDM4E (1.00) | KDM4EALDH1A1MAPK1HIF1AHSD17B10 | |
| SCHEMBL5259047 | 1.00 | KDM4E (1.00) | KDM4EALDH1A1MAPK1HIF1AHSD17B10 | |
| SCHEMBL3170744 | 1.00 | KDM4E (1.00) | KDM4EALDH1A1MAPK1HIF1AHSD17B10 | |
| SCHEMBL5943274 | 0.89 | KDM4E (0.80) | KDM4EALDH1A1MAPK1HIF1AHSD17B10 | |
| SCHEMBL5943277 | 0.89 | KDM4E (0.80) | KDM4EALDH1A1MAPK1HIF1AHSD17B10 | |
| SCHEMBL24852454 | 0.88 | KDM4E (0.79) | KDM4EALDH1A1MAPK1HIF1APGR | |
| SCHEMBL5708128 | 0.88 | KDM4E (0.79) | KDM4EALDH1A1MAPK1HIF1APGR | |
| SCHEMBL5708123 | 0.88 | KDM4E (0.79) | KDM4EALDH1A1MAPK1HIF1APGR | |
| SCHEMBL24525578 | 0.88 | KDM4E (0.79) | KDM4EALDH1A1MAPK1HIF1APGR | |
| SCHEMBL6152790 | 0.86 | KDM4E (0.76) | KDM4EALDH1A1MAPK1HIF1AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1395603-B1 | PREPARATION OF FLUMETHASONE AND ITS 17-CARBOXYL ANDROSTEN ANALOGUE | HOVIONE LTD (CN) | 2010-03-10 | — | — | EP | disclosed |
| US-6528666-B1 | C3 protecting 9,11-epoxy-17,21-dihydroxy-16-methylpregna-1,4-diene-3,20-dione,21-acetate; fluorinating at 6 alpha; depro-tecting and fluorinating epoxy group; simultaneous hydrolysis and oxidative degradation with methanolic potassium hydroxide | HORIONE LIMITED (HK) | 2003-03-04 | — | — | US | disclosed |