Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.70 |
| ▸ | NPC1 | O15118 | 1/20 | 0.70 |
| ▸ | HPGD | P15428 | 1/20 | 0.70 |
| ▸ | POLB | P06746 | 2/20 | 0.69 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.64 |
| ▸ | ME2 | P23368 | 1/20 | 0.61 |
| ▸ | ME1 | P48163 | 1/20 | 0.61 |
| ▸ | ME3 | Q16798 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.54 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.53 |
| ▸ | ECE2 | P0DPD6 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26179616 | 0.98 | POLB (0.71) | SMN1; SMN2NPC1HPGDPOLBHSD11B1 | |
| SCHEMBL8908929 | 0.84 | POLB (0.67) | SMN1; SMN2NPC1HPGDPOLBHSD11B1 | |
| SCHEMBL2240974 | 0.84 | SMN1; SMN2 (0.72) | SMN1; SMN2NPC1HPGDPOLBHSD11B1 | |
| SCHEMBL2236040 | 0.84 | SMN1; SMN2 (0.72) | SMN1; SMN2NPC1HPGDPOLBALDH1A1 | |
| SCHEMBL4548020 | 0.83 | POLB (0.69) | SMN1; SMN2POLBHSD11B1ALDH1A1ME2 | |
| SCHEMBL13900106 | 0.83 | NPC1 (0.68) | NPC1POLBALDH1A1ME2ME1 | |
| Hydrochloric Acid SCHEMBL21681605 | 0.83 | POLB (0.65) | SMN1; SMN2NPC1HPGDPOLBHSD11B1 | |
| SCHEMBL6618388 | 0.83 | POLB (0.65) | SMN1; SMN2NPC1HPGDPOLBHSD11B1 | |
| SCHEMBL31335307 | 0.82 | HPGD (1.00) | SMN1; SMN2NPC1HPGDPOLBALDH1A1 | |
| SCHEMBL9528958 | 0.82 | HPGD (0.70) | SMN1; SMN2NPC1HPGDPOLBHSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7652058-B2 | Octahydropyrano[3,4-C]pyrrole tachykinin receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2010-01-26 | — | — | US | disclosed |
| US-20090048248-A1 | Octahydropyrano[3,4-C]Pyrrole Tachykinin Receptor Antagonists | MERCK SHARP & DOHME CORP. | 2009-02-19 | — | — | US | disclosed |
| EP-1965794-A2 | OCTAHYDROPYRANO[3,4-C]PYRROLE TACHYKININ RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 2008-09-10 | — | — | EP | disclosed |
| US-20080108689-A1 | Octahydropyrano[3,4-C]Pyrrole Tachykinin Receptor Antagonists | MERCK SHARP & DOHME CORP. | 2008-05-08 | — | — | US | disclosed |
| WO-2007075528-A2 | OCTAHYDROPYRANO[3,4-C]PYRROLE TACHYKININ RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2007-07-05 | — | — | WO | disclosed |
| EP-0252474-B1 | HYDRAZINE DERIVATIVES | AMERICAN CYANAMID COMPANY (US) | 1993-04-21 | — | — | EP | disclosed |
| EP-0525832-A1 | Substituted 1,2,3- thiadiazole-4-thiolates | AMERICAN CYANAMID COMPANY (US) | 1993-02-03 | — | — | EP | disclosed |
| US-4916237-A | Substituted 1,2,3-thiadiazole-4-thiolates | AMERICAN CYANAMID COMPANY (US) | 1990-04-10 | — | — | US | disclosed |
| US-4803280-A | Substituted 1,2,3-thia-diazole-4-thiolates | AMERICAN CYANAMID COMPANY (US) | 1989-02-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080108689-A1 | Octahydropyrano[3,4-C]Pyrrole Tachykinin Receptor Antagonists | TACR1, TACR2, NPSR1 | SMN1; SMN2 3562/4885NPC1 2471/4885HPGD 286/4885 |
| US-20090048248-A1 | Octahydropyrano[3,4-C]Pyrrole Tachykinin Receptor Antagonists | TACR1, TACR2, NPSR1 | SMN1; SMN2 3484/4885NPC1 2520/4885HPGD 263/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.