Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 6/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.70 |
| ▸ | NPC1 | O15118 | 3/20 | 0.70 |
| ▸ | RAB9A | P51151 | 5/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.65 |
| ▸ | GAA | P10253 | 1/20 | 0.65 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.64 |
| ▸ | GFER | P55789 | 1/20 | 0.63 |
| ▸ | ATM | Q13315 | 1/20 | 0.63 |
| ▸ | ME2 | P23368 | 1/20 | 0.61 |
| ▸ | ME1 | P48163 | 1/20 | 0.61 |
| ▸ | ME3 | Q16798 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7430480 | 0.98 | HPGD (0.67) | HPGDSMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL26100265 | 0.87 | HPGD (0.55) | HPGDSMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL4671683 | 0.84 | GFER (0.61) | HPGDSMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL2236040 | 0.84 | SMN1; SMN2 (0.72) | HPGDSMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL2240974 | 0.84 | SMN1; SMN2 (0.72) | HPGDSMN1; SMN2NPC1ALDH1A1GAA | |
| SCHEMBL22217034 | 0.84 | SMN1; SMN2 (0.67) | HPGDSMN1; SMN2NPC1ALDH1A1GFER | |
| SCHEMBL24352145 | 0.83 | KMT2A (0.72) | NPC1RAB9AALDH1A1GFERATM | |
| SCHEMBL15134817 | 0.83 | MAPT (0.68) | HPGDSMN1; SMN2GAAHSD11B1GFER | |
| SCHEMBL654067 | 0.83 | GFER (0.60) | HPGDSMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL26134296 | 0.83 | CHRM1 (0.67) | NPC1RAB9AALDH1A1HSD11B1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0252474-B1 | HYDRAZINE DERIVATIVES | AMERICAN CYANAMID COMPANY (US) | 1993-04-21 | — | — | EP | disclosed |
| EP-0525832-A1 | Substituted 1,2,3- thiadiazole-4-thiolates | AMERICAN CYANAMID COMPANY (US) | 1993-02-03 | — | — | EP | disclosed |
| US-4916237-A | Substituted 1,2,3-thiadiazole-4-thiolates | AMERICAN CYANAMID COMPANY (US) | 1990-04-10 | — | — | US | disclosed |
| US-4803280-A | Substituted 1,2,3-thia-diazole-4-thiolates | AMERICAN CYANAMID COMPANY (US) | 1989-02-07 | — | — | US | disclosed |
| EP-0252474-A2 | Hydrazine derivatives | AMERICAN CYANAMID COMPANY (US) | 1988-01-13 | — | — | EP | disclosed |