Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM6B | O15054 | 3/20 | 0.50 |
| ▸ | KDM2B | Q8NHM5 | 3/20 | 0.50 |
| ▸ | CHRNA1 | P02708 | 2/20 | 0.50 |
| ▸ | MAOB | P27338 | 2/20 | 0.50 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.50 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.50 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.50 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.50 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.50 |
| ▸ | PHF8 | Q9UPP1 | 2/20 | 0.50 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.50 |
| ▸ | AHR | P35869 | 1/20 | 0.50 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.50 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.50 |
| ▸ | GBA1 | P04062 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.47 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3175655 | 0.92 | GBA1 (0.47) | KDM6BKDM2BCHRNA1MAOBOPRM1 | |
| SCHEMBL3170371 | 0.91 | KDM6A (0.48) | KDM6BKDM2BCHRNA1MAOBOPRM1 | |
| SCHEMBL3161894 | 0.89 | ALDH1A1 (0.47) | KDM6BKDM2BCHRNA1MAOBOPRM1 | |
| SCHEMBL3163116 | 0.88 | KDM6B (0.50) | KDM6BKDM2BCHRNA1MAOBOPRM1 | |
| SCHEMBL3164783 | 0.87 | KDM6B (0.45) | KDM6BKDM2BCHRNA1MAOBOPRM1 | |
| SCHEMBL3258026 | 0.87 | PTK2 (0.46) | KDM6BKDM2BCHRNA1MAOBOPRM1 | |
| SCHEMBL3155347 | 0.86 | GBA1 (0.49) | KDM6BKDM2BCHRNA1MAOBOPRM1 | |
| SCHEMBL3166309 | 0.86 | GBA1 (0.48) | KDM6BKDM2BCHRNA1MAOBOPRM1 | |
| SCHEMBL3171321 | 0.85 | GBA1 (0.54) | KDM6BKDM2BCHRNA1MAOBOPRM1 | |
| SCHEMBL3165783 | 0.85 | USP2 (0.43) | KDM6BKDM2BCHRNA1MAOBOPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1465631-B1 | PYRIMIDINE A2B SELECTIVE ANTAGONIST COMPOUNDS, THEIR SYNTHESIS AND USE | OSI PHARM INC (US) | 2010-02-24 | — | — | EP | disclosed |