Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Ce-224535. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 known ✓ | Q99572 | 20/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ce-224535 SCHEMBL3475321 | 1.00 | P2RX7 (1.00) | P2RX7 | |
| Ce-224535 SCHEMBL3473554 | 1.00 | P2RX7 (1.00) | P2RX7 | |
| SCHEMBL13433834 | 1.00 | P2RX7 (1.00) | P2RX7 | |
| SCHEMBL3473601 | 1.00 | P2RX7 (1.00) | P2RX7 | |
| Ce-224535 SCHEMBL3473047 | 1.00 | P2RX7 (1.00) | P2RX7 | |
| SCHEMBL13433833 | 1.00 | P2RX7 (1.00) | P2RX7 | |
| SCHEMBL3475207 | 1.00 | P2RX7 (1.00) | P2RX7 | |
| SCHEMBL3472374 | 0.99 | P2RX7 (0.98) | P2RX7 | |
| SCHEMBL13433836 | 0.99 | P2RX7 (0.98) | P2RX7 | |
| SCHEMBL13433835 | 0.99 | P2RX7 (0.98) | P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025229484-A1 | PURINERGIC P2 RECEPTOR ANTAGONISTS FOR USE IN THE TREATMENT OF CONGENITAL SIDEROBLASTIC ANEMIAS | UNIVERSITÀ DEGLI STUDI DI BARI ALDO MORO (IT) | 2025-11-06 | — | — | WO | disclosed |