Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 11/20 | 0.53 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.44 |
| ▸ | MELK | Q14680 | 1/20 | 0.44 |
| ▸ | STK24 | Q9Y6E0 | 1/20 | 0.44 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 2/20 | 0.38 |
| ▸ | AHR | P35869 | 2/20 | 0.37 |
| ▸ | CMA1 | P23946 | 1/20 | 0.37 |
| ▸ | TNF | P01375 | 1/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.35 |
| ▸ | TYMS | P04818 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6804986 | 0.81 | CHEK1 (0.56) | CHEK1JAK2RPS6KA3MELKSTK24 | |
| SCHEMBL30727439 | 0.81 | CHEK1 (0.56) | CHEK1JAK2RPS6KA3MELKSTK24 | |
| SCHEMBL24803891 | 0.78 | CHEK1 (0.45) | CHEK1JAK2RPS6KA3MELKSTK24 | |
| SCHEMBL29701184 | 0.78 | CHEK1 (0.45) | CHEK1JAK2RPS6KA3MELKSTK24 | |
| SCHEMBL19785546 | 0.76 | — | — | |
| SCHEMBL15830711 | 0.74 | CHEK1 (0.49) | CHEK1JAK2RPS6KA3MELKSTK24 | |
| SCHEMBL3117561 | 0.73 | JAK2 (0.61) | CHEK1JAK2RPS6KA3MELKSTK24 | |
| SCHEMBL28870331 | 0.73 | CHEK1 (0.51) | CHEK1JAK2RPS6KA3MELKSTK24 | |
| SCHEMBL15662861 | 0.72 | TNF (0.59) | CHEK1CSNK2A1AHRCMA1TNF | |
| SCHEMBL31058113 | 0.72 | TNF (0.59) | CHEK1CSNK2A1AHRCMA1TNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4647433-A1 | SHP2 INHIBITOR AND USES THEREOF | Kanaph Therapeutics Inc. (KR) | 2025-11-12 | — | — | EP | disclosed |