SCHEMBL31727437

SCHEMBL31727437

CC(C)(C)OC(=O)N1CCC2(CC1)CCN(c1ccc3c(c1)C(=O)N([C@@H]1CCC(=O)NC1=O)C3)CC2

nearest known ligand 0.52

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
▸ CRBN Q96SW2 19/20 0.52
▸ DDB1 Q16531 3/20 0.48
▸ GSPT1 P15170 1/20 0.43
▸ MAP1LC3B Q9GZQ8 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29913936 0.94 CRBN (0.52) CRBNDDB1GSPT1MAP1LC3B
SCHEMBL22291534 0.94 CRBN (0.52) CRBNDDB1GSPT1MAP1LC3B
SCHEMBL31726811 0.93 CRBN (0.52) CRBNDDB1GSPT1
SCHEMBL22498388 0.93 CRBN (0.52) CRBNDDB1GSPT1
SCHEMBL27376752 0.93 CRBN (0.56) CRBNDDB1GSPT1
SCHEMBL29614584 0.93 CRBN (0.56) CRBNDDB1GSPT1
SCHEMBL20046720 0.93 CRBN (0.56) CRBNDDB1GSPT1
SCHEMBL30984958 0.89 CRBN (0.51) CRBNDDB1GSPT1
SCHEMBL31726978 0.88 CRBN (0.54) CRBNDDB1
SCHEMBL20234853 0.88 CRBN (0.52) CRBNDDB1GSPT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025235363-A1 CYCLIN-DEPENDENT KINASE 4 DEGRADERS BLUEPRINT MEDICINES CORPORATION (US) 2025-11-13 — — WO disclosed
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