SCHEMBL3173166

SCHEMBL3173166

Cc1c(Nc2cc(F)c(C#N)cc2F)ncnc1OC1CCN(OC(=O)OC(C)C)CC1

nearest known ligand 0.54

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GPR119 Q8TDV5 20/20 0.54
CYP2C9 P11712 3/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL389468 0.89 GPR119 (0.69) GPR119CYP2C9
SCHEMBL3160646 0.89 GPR119 (0.57) GPR119CYP2C9
SCHEMBL3169978 0.88 GPR119 (0.59) GPR119CYP2C9
SCHEMBL3160615 0.86 GPR119 (0.55) GPR119CYP2C9
SCHEMBL4723713 0.85 GPR119 (0.53) GPR119
SCHEMBL3164266 0.85 GPR119 (0.54) GPR119CYP2C9
SCHEMBL3174748 0.84 GPR119 (0.53) GPR119CYP2C9
SCHEMBL3167810 0.84 GPR119 (0.53) GPR119CYP2C9
SCHEMBL3170641 0.84 GPR119 (0.62) GPR119CYP2C9
SCHEMBL3170405 0.84 GPR119 (0.52) GPR119CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1644357-B9 TRISUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF METABOLISM AND THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO ARENA PHARM INC (US) 2010-03-24 EP claimed
EP-1644357-B1 TRISUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF METABOLISM AND THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO ARENA PHARM INC (US) 2007-12-12 EP claimed