Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.41 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | BAZ1A | Q9NRL2 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3174017 | 1.00 | MAPT (0.52) | MAPTCYP3A4ALDH1A1L3MBTL1PTGS2 | |
| SCHEMBL3173460 | 0.95 | MAPT (0.52) | MAPTCYP3A4ALDH1A1L3MBTL1PTGS2 | |
| SCHEMBL3173449 | 0.95 | MAPT (0.52) | MAPTCYP3A4ALDH1A1L3MBTL1PTGS2 | |
| SCHEMBL3176416 | 0.85 | KMT2A (0.47) | MAPTCYP3A4ALDH1A1L3MBTL1PTGS2 | |
| SCHEMBL3176429 | 0.85 | KMT2A (0.47) | MAPTCYP3A4ALDH1A1L3MBTL1PTGS2 | |
| SCHEMBL13524148 | 0.82 | MAPT (0.67) | MAPTALDH1A1PTGS2RAB9AKDM4E | |
| SCHEMBL3173935 | 0.81 | ALDH1A1 (0.50) | MAPTCYP3A4ALDH1A1L3MBTL1RAB9A | |
| SCHEMBL3168611 | 0.81 | KMT2A (0.47) | MAPTCYP3A4ALDH1A1PTGS2RAB9A | |
| SCHEMBL3168625 | 0.81 | KMT2A (0.47) | MAPTCYP3A4ALDH1A1PTGS2RAB9A | |
| SCHEMBL27624729 | 0.79 | MAPT (0.41) | MAPTCYP3A4ALDH1A1L3MBTL1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7645760-B2 | 1-(4-Benzyl-piperazin-1-yl)-3-phenyl-propenone derivatives | NOVARTIS AG. (CH) | 2010-01-12 | — | — | US | disclosed |
| US-7645760-B2 | 1-(4-Benzyl-piperazin-1-yl)-3-phenyl-propenone derivatives | NOVARTIS AG. (CH) | 2010-01-12 | — | — | US | disclosed |
| US-20060173004-A1 | 1-(4-Benzyl-piperazin-1-yl)-3-phenyl-propenone derivatives | NOVARTIS AG (CH) | 2006-08-03 | — | — | US | disclosed |
| EP-1558594-A2 | 1-(4-BENZYL-PIPERAZIN-1-YL)-3-PHENYL-PROPENONE DERIVATIVES | Novartis AG (CH) | 2005-08-03 | — | — | EP | disclosed |
| WO-2004037796-A2 | 1-(4-BENZYL-PIPERAZIN-1-YL)-3-PHENYL-PROPENONE DERIVATIVES | NOVARTIS AG (CH) | 2004-05-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060173004-A1 | 1-(4-Benzyl-piperazin-1-yl)-3-phenyl-propenone derivatives | CCR1, CCR3, CCR4 | MAPT 2279/4885CYP3A4 1170/4885ALDH1A1 290/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.