Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 12/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 7/20 | 0.38 |
| ▸ | MAPK12 | P53778 | 5/20 | 0.38 |
| ▸ | MAPK11 | Q15759 | 4/20 | 0.38 |
| ▸ | PTK2B | Q14289 | 2/20 | 0.35 |
| ▸ | CDK8 | P49336 | 3/20 | 0.34 |
| ▸ | DDR2 | Q16832 | 2/20 | 0.34 |
| ▸ | HCK | P08631 | 2/20 | 0.33 |
| ▸ | CIT | O14578 | 1/20 | 0.33 |
| ▸ | MUSK | O15146 | 1/20 | 0.33 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.33 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.33 |
| ▸ | STK10 | O94804 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | TNF | P01375 | 1/20 | 0.33 |
| ▸ | RAF1 | P04049 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3389381 | 0.86 | KCNJ6 (0.40) | MAPK14MAPK13MAPK12MAPK11HCK | |
| SCHEMBL3174424 | 0.85 | MAPK14 (0.45) | MAPK14MAPK13MAPK12MAPK11PTK2B | |
| SCHEMBL3388827 | 0.84 | MAPK14 (0.38) | MAPK14MAPK13MAPK12MAPK11HCK | |
| SCHEMBL3174613 | 0.83 | MAPK14 (0.47) | MAPK14MAPK13MAPK12MAPK11PTK2B | |
| SCHEMBL3392522 | 0.83 | MAPK14 (0.36) | MAPK14MAPK13MAPK12MAPK11PTK2B | |
| SCHEMBL3180417 | 0.78 | MAPK14 (0.37) | MAPK14MAPK13MAPK12MAPK11PTK2B | |
| SCHEMBL4481650 | 0.77 | MAPK14 (0.37) | MAPK14MAPK13MAPK12MAPK11PTK2B | |
| SCHEMBL3180282 | 0.77 | MAPK14 (0.55) | MAPK14MAPK13MAPK12MAPK11PTK2B | |
| SCHEMBL3388897 | 0.76 | KCNJ6 (0.41) | MAPK14MAPK13MAPK12MAPK11CDK8 | |
| SCHEMBL3392537 | 0.76 | MAPK14 (0.37) | MAPK14MAPK13MAPK12MAPK11PTK2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1943243-B1 | KINASE INHIBITORS | LILLY CO ELI (US) | 2010-12-29 | — | — | EP | disclosed |
| US-7652015-B2 | Suppression cytokines , tumor necrosis factor | ELI LILLY AND COMPANY (US) | 2010-01-26 | — | — | US | disclosed |
| US-20080269244-A1 | Kinase Inhibitors | ELI LILLY AND COMPANY | 2008-10-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080269244-A1 | Kinase Inhibitors | MAP3K1, MAP3K20, MAP3K19 | MAPK14 58/4885MAPK13 60/4885MAPK12 78/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.