Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 16/20 | 0.36 |
| ▸ | MAPK12 | P53778 | 4/20 | 0.36 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.36 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.36 |
| ▸ | GSK3A | P49840 | 2/20 | 0.35 |
| ▸ | HCK | P08631 | 2/20 | 0.34 |
| ▸ | BRAF | P15056 | 2/20 | 0.34 |
| ▸ | SRC | P12931 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3180417 | 0.96 | MAPK14 (0.37) | MAPK14MAPK12MAPK13MAPK11GSK3A | |
| SCHEMBL3387984 | 0.87 | KCNJ6 (0.39) | MAPK14MAPK12MAPK13MAPK11HCK | |
| SCHEMBL3392519 | 0.86 | MAPK14 (0.43) | MAPK14MAPK12MAPK13MAPK11GSK3A | |
| SCHEMBL3392556 | 0.84 | MAPK14 (0.45) | MAPK14MAPK12MAPK13MAPK11GSK3A | |
| SCHEMBL3174433 | 0.83 | MAPK14 (0.38) | MAPK14MAPK12MAPK13MAPK11HCK | |
| SCHEMBL3170652 | 0.83 | MAPK14 (0.36) | MAPK14MAPK12MAPK13MAPK11GSK3A | |
| SCHEMBL4481650 | 0.82 | MAPK14 (0.37) | MAPK14MAPK12MAPK13MAPK11GSK3A | |
| SCHEMBL3180405 | 0.81 | MAPK14 (0.43) | MAPK14MAPK12MAPK13MAPK11GSK3A | |
| SCHEMBL3170645 | 0.80 | MAPK14 (0.49) | MAPK14MAPK12MAPK13MAPK11GSK3A | |
| SCHEMBL3171227 | 0.80 | MAPK14 (0.46) | MAPK14MAPK12MAPK13MAPK11BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1943243-B1 | KINASE INHIBITORS | LILLY CO ELI (US) | 2010-12-29 | — | — | EP | disclosed |