SCHEMBL31746927

SCHEMBL31746927

Cc1cc(Nc2cccc3ccn(CC(=O)NCC(F)(F)F)c(=O)c23)cc2[nH]ncc12

nearest known ligand 0.39

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
DDR1 Q08345 13/20 0.39
MEN1 O00255 2/20 0.37
KMT2A Q03164 2/20 0.37
RAB9A P51151 1/20 0.37
KDM4E B2RXH2 2/20 0.36
LMNA P02545 3/20 0.36
USP2 O75604 2/20 0.36
MAPK1 P28482 2/20 0.36
TSHR P16473 1/20 0.36
HTT P42858 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
ALDH1A1 P00352 1/20 0.35
HPGD P15428 1/20 0.35
NPSR1 Q6W5P4 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25073790 1.00 DDR1 (0.39) DDR1MEN1KMT2ARAB9AKDM4E
SCHEMBL25073892 0.88 DDR1 (0.39) DDR1KDM4ELMNAUSP2MAPK1
SCHEMBL31746926 0.88 DDR1 (0.39) DDR1KDM4ELMNAUSP2MAPK1
SCHEMBL31746920 0.88 DDR1 (0.43) DDR1MEN1KMT2ARAB9AKDM4E
SCHEMBL25073872 0.88 DDR1 (0.43) DDR1MEN1KMT2ARAB9AKDM4E
SCHEMBL25073910 0.87 DDR1 (0.42) DDR1MAPK1HPGD
SCHEMBL31746900 0.87 DDR1 (0.42) DDR1MAPK1HPGD
SCHEMBL25073903 0.86 DDR1 (0.44) DDR1
SCHEMBL31746911 0.86 DDR1 (0.44) DDR1
SCHEMBL25073913 0.85 DDR1 (0.38) DDR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4387963-B1 PHENYL- AND PYRIDOPYRAZOLE DERIVATIVES AS INHIBITORS OF DDR1 REDX PHARMA LTD (GB) 2025-12-24 EP disclosed