Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.38 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.38 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | FABP5 | Q01469 | 2/20 | 0.37 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.37 |
| ▸ | FABP7 | O15540 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MDM4 | O15151 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21837839 | 1.00 | LMNA (0.41) | LMNAEPHX1TBXAS1ITGB3ITGA2B | |
| SCHEMBL21837837 | 1.00 | LMNA (0.41) | LMNAEPHX1TBXAS1ITGB3ITGA2B | |
| SCHEMBL30055479 | 1.00 | LMNA (0.41) | LMNAEPHX1TBXAS1ITGB3ITGA2B | |
| SCHEMBL29633870 | 1.00 | LMNA (0.41) | LMNAEPHX1TBXAS1ITGB3ITGA2B | |
| SCHEMBL31369615 | 1.00 | LMNA (0.41) | LMNAEPHX1TBXAS1ITGB3ITGA2B | |
| Trifluoroacetic Acid SCHEMBL23501838 | 0.94 | LMNA (0.39) | LMNAEPHX1TBXAS1ITGB3ITGA2B | |
| Trifluoroacetic Acid SCHEMBL30277750 | 0.94 | LMNA (0.39) | LMNAEPHX1TBXAS1ITGB3ITGA2B | |
| Trifluoroacetic Acid SCHEMBL23501837 | 0.94 | LMNA (0.39) | LMNAEPHX1TBXAS1ITGB3ITGA2B | |
| SCHEMBL25182955 | 0.90 | CHRNA7 (0.39) | LMNAEPHX1TBXAS1FABP5KCNA5 | |
| SCHEMBL25182953 | 0.90 | CHRNA7 (0.39) | LMNAEPHX1TBXAS1FABP5KCNA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260001914-A1 | MACROCYCLIC PEPTIDES TARGETING KRAS | MERCK SHARP & DOHME LLC (US) | 2026-01-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260001914-A1 | MACROCYCLIC PEPTIDES TARGETING KRAS | KRAS, NRAS, HRAS | LMNA 1586/4885EPHX1 2937/4885TBXAS1 4519/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.