Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | KDM6B | O15054 | 3/20 | 0.41 |
| ▸ | KDM2B | Q8NHM5 | 3/20 | 0.41 |
| ▸ | CHRNA1 | P02708 | 2/20 | 0.41 |
| ▸ | MAOB | P27338 | 2/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.41 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.41 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.41 |
| ▸ | PHF8 | Q9UPP1 | 2/20 | 0.41 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.41 |
| ▸ | AHR | P35869 | 1/20 | 0.41 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.41 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3170999 | 0.94 | TP53 (0.46) | TP53KDM6BKDM2BCHRNA1MAOB | |
| SCHEMBL3166436 | 0.83 | MAPT (0.48) | SMN1; SMN2ADORA2AADORA1ALDH1A1LMNA | |
| SCHEMBL3155347 | 0.82 | GBA1 (0.49) | KDM6BKDM2BCHRNA1MAOBOPRM1 | |
| SCHEMBL3155862 | 0.81 | MAPT (0.48) | KDM6BKDM2BCHRNA1MAOBOPRM1 | |
| SCHEMBL3164739 | 0.81 | LMNA (0.48) | KDM6BKDM2BCHRNA1MAOBOPRM1 | |
| SCHEMBL3171321 | 0.81 | GBA1 (0.54) | KDM6BKDM2BCHRNA1MAOBOPRM1 | |
| SCHEMBL3164845 | 0.81 | KDM6B (0.49) | KDM6BKDM2BCHRNA1MAOBOPRM1 | |
| SCHEMBL3174564 | 0.81 | GBA1 (0.50) | KDM6BKDM2BCHRNA1MAOBOPRM1 | |
| SCHEMBL3170062 | 0.80 | KDM6B (0.42) | KDM6BKDM2BCHRNA1MAOBOPRM1 | |
| SCHEMBL3172228 | 0.80 | KMT2A (0.52) | KDM6BKDM2BCHRNA1MAOBOPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1465631-B1 | PYRIMIDINE A2B SELECTIVE ANTAGONIST COMPOUNDS, THEIR SYNTHESIS AND USE | OSI PHARM INC (US) | 2010-02-24 | — | — | EP | disclosed |