Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | GBA1 | P04062 | 2/20 | 0.43 |
| ▸ | KDM6B | O15054 | 3/20 | 0.43 |
| ▸ | KDM2B | Q8NHM5 | 3/20 | 0.43 |
| ▸ | CHRNA1 | P02708 | 2/20 | 0.43 |
| ▸ | MAOB | P27338 | 2/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3172676 | 0.92 | GBA1 (0.43) | LMNAALDH1A1HTTUSP2GAA | |
| SCHEMBL3175804 | 0.91 | GBA1 (0.51) | LMNAALDH1A1MEN1KMT2APOLB | |
| SCHEMBL3171321 | 0.89 | GBA1 (0.54) | LMNAALDH1A1MEN1KMT2APOLB | |
| SCHEMBL3155347 | 0.89 | GBA1 (0.49) | LMNAALDH1A1GBA1KDM6BKDM2B | |
| SCHEMBL3166309 | 0.88 | GBA1 (0.48) | LMNAALDH1A1HTTMAPTGBA1 | |
| SCHEMBL3163092 | 0.88 | KDM6B (0.43) | LMNAALDH1A1USP2MAPTPOLB | |
| SCHEMBL3172356 | 0.88 | GBA1 (0.45) | LMNAALDH1A1MAPTALOX15HSD17B10 | |
| SCHEMBL3163851 | 0.88 | GBA1 (0.48) | LMNAALDH1A1POLBGBA1KDM6B | |
| SCHEMBL3172414 | 0.88 | GBA1 (0.50) | LMNAALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL3175858 | 0.87 | SLC6A7 (0.48) | LMNAALDH1A1USP2MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1465631-B1 | PYRIMIDINE A2B SELECTIVE ANTAGONIST COMPOUNDS, THEIR SYNTHESIS AND USE | OSI PHARM INC (US) | 2010-02-24 | — | — | EP | disclosed |