Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 14/20 | 0.54 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 2/20 | 0.40 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL316838 | 0.81 | PTGDR2 (0.79) | PTGDR2PTGS1CYP2C9SLC6A4CYP2C19 | |
| SCHEMBL317770 | 0.74 | PTGDR2 (0.44) | PTGDR2PTGS1CYP2C9SLC6A4CYP2C19 | |
| SCHEMBL317222 | 0.73 | PTGDR2 (0.78) | PTGDR2PTGS1CYP2C9SLC6A4CYP2C19 | |
| SCHEMBL318053 | 0.69 | PTGDR2 (0.75) | PTGDR2PTGS1CYP2C9SLC6A4CYP2C19 | |
| SCHEMBL28514481 | 0.68 | IDO1 (0.45) | IDO1AAK1 | |
| SCHEMBL28514483 | 0.68 | IDO1 (0.45) | IDO1AAK1 | |
| SCHEMBL317229 | 0.68 | PTGDR2 (1.00) | PTGDR2PTGS1CYP2C9SLC6A4CYP2C19 | |
| SCHEMBL317490 | 0.68 | PTGDR2 (0.88) | PTGDR2PTGS1CYP2C9SLC6A4CYP2C19 | |
| SCHEMBL317503 | 0.66 | KIF11 (0.46) | PTGDR2PTGS1PTGS2IDO1 | |
| SCHEMBL318388 | 0.66 | PTGDR2 (0.83) | PTGDR2PTGS1CYP2C9SLC6A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8093278-B2 | Substituted indoles | ASTRAZENECA AB (SE) | 2012-01-10 | — | — | US | disclosed |