Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NSD2 | O96028 | 1/20 | 0.68 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.64 |
| ▸ | ATM | Q13315 | 1/20 | 0.64 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.58 |
| ▸ | USP2 | O75604 | 1/20 | 0.57 |
| ▸ | APEX1 | P27695 | 1/20 | 0.57 |
| ▸ | METAP2 | P50579 | 1/20 | 0.56 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.56 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.56 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.56 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.56 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7535584 | 0.87 | USP2 (0.68) | KMT2ALMNAHPGDUSP2MEN1 | |
| SCHEMBL5525382 | 0.84 | EGLN1 (0.60) | NSD2MAPK8ATMEGLN1KMT2A | |
| SCHEMBL31569526 | 0.83 | NSD2 (0.66) | NSD2MAPK8ATMEGLN1KMT2A | |
| SCHEMBL8154709 | 0.83 | KMT2A (0.80) | NSD2MAPK8ATMEGLN1KMT2A | |
| SCHEMBL13139170 | 0.83 | ATM (0.67) | NSD2MAPK8ATMEGLN1KMT2A | |
| SCHEMBL6382378 | 0.83 | HPGD (0.69) | KMT2ALMNAHPGDL3MBTL1MEN1 | |
| SCHEMBL920392 | 0.83 | NSD2 (0.66) | NSD2MAPK8ATMEGLN1KMT2A | |
| SCHEMBL12142857 | 0.83 | NSD2 (0.66) | NSD2MAPK8ATMEGLN1KMT2A | |
| SCHEMBL922492 | 0.83 | NSD2 (0.66) | NSD2MAPK8ATMEGLN1KMT2A | |
| SCHEMBL31680569 | 0.81 | KMT2A (0.89) | NSD2KMT2ALMNAGAAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100016379-A1 | Terephthalamate Compounds and Compositions, and Their Use as HIV Integrase Inhibitors | IRM LLC (BM) | 2010-01-21 | — | — | US | disclosed |
| US-20100016379-A1 | Terephthalamate Compounds and Compositions, and Their Use as HIV Integrase Inhibitors | IRM LLC (BM) | 2010-01-21 | — | — | US | disclosed |
| US-20100016379-A1 | Terephthalamate Compounds and Compositions, and Their Use as HIV Integrase Inhibitors | IRM LLC (BM) | 2010-01-21 | — | — | US | disclosed |
| WO-2008073138-A2 | TEREPHTHALAMATE COMPOUNDS AND COMPOSITIONS, AND THEIR USE AS HIV INTEGRASE INHIBITORS | IRM LLC (BM) | 2008-06-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100016379-A1 | Terephthalamate Compounds and Compositions, and Their Use as HIV Integrase Inhibitors | TYMP, TYMS, IMPDH1 | NSD2 1648/4885MAPK8 2802/4885ATM 1343/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.