Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 14/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 13/20 | 0.38 |
| ▸ | SHBG | P04278 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | RBP1 | P09455 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10109578 | 1.00 | ESR1 (0.38) | ESR1ESR2SHBGSLC6A4RBP1 | |
| SCHEMBL319616 | 0.87 | ESR1 (0.42) | ESR1ESR2SHBGRBP1 | |
| SCHEMBL10109577 | 0.87 | ESR1 (0.42) | ESR1ESR2SHBGRBP1 | |
| SCHEMBL10109581 | 0.86 | ESR1 (0.40) | ESR1ESR2SHBGRBP1 | |
| SCHEMBL318531 | 0.86 | ESR1 (0.40) | ESR1ESR2SHBGRBP1 | |
| SCHEMBL10109562 | 0.86 | SHBG (0.45) | ESR1ESR2SHBGSLC6A4HTR1A | |
| SCHEMBL318456 | 0.86 | SHBG (0.45) | ESR1ESR2SHBGSLC6A4HTR1A | |
| SCHEMBL10109580 | 0.85 | ESR1 (0.44) | ESR1ESR2SHBGRBP1 | |
| SCHEMBL317982 | 0.85 | ESR1 (0.44) | ESR1ESR2SHBGRBP1 | |
| SCHEMBL5314245 | 0.85 | ESR1 (0.43) | ESR1ESR2SHBGHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8093302-B2 | Substituted tetralins as selective estrogen receptor-β agonists | ELI LILLY AND COMPANY (US) | 2012-01-10 | — | — | US | disclosed |
| US-20100249075-A1 | SUBSTITUTED TETRALINS AS SELECTIVE ESTROGEN RECEPTOR-BETA AGONISTS | ELI LILLY AND COMPANY (US) | 2010-09-30 | — | — | US | disclosed |
| EP-1853578-A1 | SUBSTITUTED TETRALINS AS SELECTIVE ESTROGEN RECEPTOR-BETA AGONISTS | ELI LILLY AND COMPANY (US) | 2007-11-14 | — | — | EP | disclosed |
| WO-2006088716-A1 | SUBSTITUTED TETRALINS AS SELECTIVE ESTROGEN RECEPTOR-BETA AGONISTS | ELI LILLY AND COMPANY (US) | 2006-08-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100249075-A1 | SUBSTITUTED TETRALINS AS SELECTIVE ESTROGEN RECEPTOR-BETA AGONISTS | ESR2, ERLIN1, ESRRG | ESR1 6/4885ESR2 1/4885SHBG 15/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.