Theobromine

Theobromine

SCHEMBL3184

Cn1cnc2c1c(=O)[nH]c(=O)n2C

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 2/20 1.00
PMP22 Q01453 2/20 1.00
MAPK1 P28482 2/20 1.00
ADORA2A P29274 4/20 0.64
PDE4A P27815 3/20 0.64
PDE4B Q07343 3/20 0.64
PDE4C Q08493 3/20 0.64
PDE4D Q08499 3/20 0.64
LMNA P02545 2/20 0.54
ALDH1A1 P00352 2/20 0.54
MAPT P10636 1/20 0.54
TSHR P16473 1/20 0.54
BLM P54132 1/20 0.54
SMN1; SMN2 Q16637 1/20 0.54
POLB P06746 2/20 0.53
GDA Q9Y2T3 2/20 0.53
PIK3CD O00329 1/20 0.53
ADORA3 P0DMS8 1/20 0.53
CNR1 P21554 1/20 0.53
ACHE P22303 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Theobromine SCHEMBL1690622 1.00 CYP3A4 (1.00) CYP3A4PMP22MAPK1ADORA2APDE4A
Theobromine SCHEMBL11599459 1.00 CYP3A4 (1.00) CYP3A4PMP22MAPK1ADORA2APDE4A
Theobromine SCHEMBL28252424 0.98 CYP3A4 (0.96) CYP3A4PMP22MAPK1ADORA2APDE4A
Theobromine SCHEMBL606388 0.98 CYP3A4 (0.96) CYP3A4PMP22MAPK1ADORA2APDE4A
Theobromine SCHEMBL6062232 0.98 CYP3A4 (0.96) CYP3A4PMP22MAPK1ADORA2APDE4A
Theobromine SCHEMBL29658415 0.98 CYP3A4 (0.96) CYP3A4PMP22MAPK1ADORA2APDE4A
Theobromine SCHEMBL7926330 0.98 CYP3A4 (0.96) CYP3A4PMP22MAPK1ADORA2APDE4A
Theobromine SCHEMBL1291169 0.98 CYP3A4 (0.96) CYP3A4PMP22MAPK1ADORA2APDE4A
Theobromine SCHEMBL4021232 0.98 CYP3A4 (0.96) CYP3A4PMP22MAPK1ADORA2APDE4A
Theobromine SCHEMBL16093810 0.96 CYP3A4 (0.93) CYP3A4PMP22MAPK1ADORA2APDE4A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 60245 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4223352-B1 DRUG-COATED BALLOON CATHETERS FOR BODY LUMENS UROTRONIC INC (US) 2026-05-27 EP claimed
EP-4747627-A1 METHODS AND SYSTEMS FOR PREDICTIVE CLASSIFICATION BY MASS SPECTROMETRY AND TRAINED LARGE SPECTRAL MODELS Matterworks Inc (US) 2026-05-27 EP claimed
US-20260138935-A1 System and method for the production of chemical compounds and nutrient optimized fertilizer from animal waste products Nalari Scientific, LLC (US) 2026-05-21 US claimed
EP-4136079-B1 BENZIMIDAZOLE COMPOUND FOR THE TREATMENT OF METABOLIC DISORDERS ACHE LABORATORIOS FARMACEUTICOS SA (BR) 2026-05-20 EP claimed
CN-119592135-B Perovskite ink composition, perovskite ink and preparation method thereof, perovskite film and preparation method and application thereof 中国石油天然气集团有限公司 2026-05-15 CN claimed
WO-2026100654-A1 NUCLEIC ACID INTRODUCTION AID, NUCLEIC ACID INTRODUCTION AGENT, AND NUCLEIC ACID INTRODUCTION METHOD 株式会社インファーマシア 2026-05-15 WO claimed
US-20260130960-A1 SYNERGISTIC HERBAL COMPOSITION WITH NOOTROPIC ACTIVITY FOR IMPROVING COGNITIVE FUNCTION AND GAMING PERFORMANCE LAILA NUTRA PRIVATE LTD (IN) 2026-05-14 US claimed
EP-4604746-B1 ORAL PRODUCT COMPRISING THEOBROMINE CONTRAF NICOTEX TOBACCO GMBH (DE) 2026-05-13 EP claimed
US-20260123649-A1 COMPOSITIONS AND METHODS FOR NUTRACEUTICAL GUMMY NOON WORLD INC (US) 2026-05-07 US claimed
US-12616727-B2 Compositions, systems, and methods for improving health UNICITY PROPERTIES, INC. (SG) 2026-05-05 US claimed
US-4390532-A MUCOPOLYSACCHARIDES, SHIN DISORDERS DR. CARL HAHN, G.M.B.H. (DE) 1983-06-28 US claimed
US-4390698-A USING AN ABSORBENT SOCIETE D'ASSISTANCE TECHNIQUE POUR PRODUITS NESTLE S.A. (CH) 1983-06-28 US claimed
EP-0074909-A1 Compositions on the basis of 5-hydroxy-tryptophane, manufacturing process and medicaments containing them S.A. PANMEDICA Société dite: (FR) 1983-03-23 EP claimed
EP-0070437-A1 Process for the elimination of stimulant compounds from cocoa SOCIETE DES PRODUITS NESTLE S.A. (CH) 1983-01-26 EP claimed
US-4288433-A THIOETHER AND A XANTHINE DERIVATIVE L'OREAL (FR) 1981-09-08 US claimed
US-4070487-A Method of stimulating appetite in ruminants and ruminant feed containing appetite stimulant HERSHEY FOODS CORPORATION (US) 1978-01-24 US claimed
US-4042442-A CAFFEINE AND THEOBROMINE AS POLYMERIZATION INITIATORS EASTMAN KODAK COMPANY (US) 1977-08-16 US claimed
US-4028184-A CULTURING CORYNEBACTERIUM, ARTHROBACTER, MICROBACTERIUM KIKKOMAN SHOYU CO., LTD. (JA) 1977-06-07 US claimed
US-4006261-A Flavoring with mixtures of theobromine and cyclic dipeptides FIRMENICH S.A. (CH) 1977-02-01 US claimed
US-3954663-A EXTRACTION, XANTHINE DERIVATIVES TEIKOKU HORININE MFG. CO. LTD. (JA) 1976-05-04 US claimed