Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 4/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.34 |
| ▸ | CHUK | O15111 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12341053 | 0.82 | ALDH1A1 (0.45) | ALDH1A1MAPTHTTGAARAB9A | |
| SCHEMBL5217375 | 0.77 | NPSR1 (0.51) | ALDH1A1HTTRAB9AMEN1KMT2A | |
| SCHEMBL27905470 | 0.74 | ALDH1A1 (0.40) | ALDH1A1MAPTHTTGAARAB9A | |
| SCHEMBL4061571 | 0.74 | ALDH1A1 (0.37) | ALDH1A1MAPTHTTGAARAB9A | |
| SCHEMBL318436 | 0.72 | ALDH1A1 (0.40) | ALDH1A1MAPTHTTGAARAB9A | |
| SCHEMBL18922765 | 0.72 | NPSR1 (0.50) | ALDH1A1MAPTHTTGAARAB9A | |
| SCHEMBL492180 | 0.70 | ALDH1A1 (0.39) | ALDH1A1MAPTHTTGAARAB9A | |
| SCHEMBL1264694 | 0.70 | MAPK1 (0.46) | ALDH1A1MAPTGAAMEN1KMT2A | |
| SCHEMBL8568179 | 0.69 | ALDH1A1 (0.53) | ALDH1A1MAPTHTTGAARAB9A | |
| SCHEMBL12343951 | 0.69 | ALDH1A1 (0.46) | ALDH1A1MAPTHTTGAARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2590968-A1 | CYCLIC ETHER COMPOUNDS USEFUL AS KINASE INHIBITORS | Novartis AG (CH) | 2013-05-15 | — | — | EP | disclosed |
| WO-2012004217-A1 | CYCLIC ETHER COMPOUNDS USEFUL AS KINASE INHIBITORS | NOVARTIS AG (CH) | 2012-01-12 | — | — | WO | disclosed |