Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.68 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.63 |
| ▸ | NR4A2 | P43354 | 5/20 | 0.55 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.54 |
| ▸ | NR1H4 | Q96RI1 | 4/20 | 0.52 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.50 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3186894 | 0.97 | KMT2A (0.63) | ALDH1A1L3MBTL1KMT2ANR4A2PLA2G4B | |
| SCHEMBL3186986 | 0.95 | KMT2A (0.61) | ALDH1A1L3MBTL1KMT2ANR4A2PLA2G4B | |
| SCHEMBL850469 | 0.92 | KMT2A (0.65) | ALDH1A1L3MBTL1KMT2ANR4A2PLA2G4B | |
| SCHEMBL9803295 | 0.87 | KMT2A (0.80) | KMT2ANR4A2PLA2G4BNR1H4PRSS1 | |
| SCHEMBL4509654 | 0.85 | KMT2A (0.77) | KMT2ANR4A2PLA2G4BNR1H4PRSS1 | |
| SCHEMBL202782 | 0.85 | PRSS1 (0.55) | ALDH1A1L3MBTL1KMT2APRSS1 | |
| SCHEMBL201121 | 0.84 | PRSS1 (0.56) | ALDH1A1L3MBTL1KMT2APRSS1 | |
| SCHEMBL201096 | 0.84 | PRSS1 (0.56) | ALDH1A1L3MBTL1KMT2APRSS1 | |
| SCHEMBL30167982 | 0.84 | KMT2A (0.80) | KMT2ANR4A2PLA2G4BNR1H4PRSS1 | |
| SCHEMBL10787479 | 0.84 | KMT2A (0.80) | KMT2ANR4A2PLA2G4BNR1H4PRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100022500-A1 | Macrocyclic Lactams and Pharmaceutical Use Thereof | NOVARTIS AG | 2010-01-28 | — | — | US | disclosed |
| US-7612055-B2 | Macrocyclic lactams and pharmaceutical use thereof | NOVARTIS AG (CH) | 2009-11-03 | — | — | US | disclosed |
| US-20070072792-A1 | Macrocyclic lactams and pharmaceutical use thereof | NOVARTIS AG (CH) | 2007-03-29 | — | — | US | disclosed |
| EP-1682521-A1 | MACROCYCLIC LACTAMS AND PHARMACEUTICAL USE THEREOF | Novartis AG (CH) | 2006-07-26 | — | — | EP | disclosed |
| WO-2005049585-A1 | MACROCYCLIC LACTAMS AND PHARMACEUTICAL USE THEREOF | NOVARTIS AG (CH) | 2005-06-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070072792-A1 | Macrocyclic lactams and pharmaceutical use thereof | RPS11, MRPL21, RPS4Y1 | ALDH1A1 4236/4885L3MBTL1 4378/4885KMT2A 3031/4885 |
| US-20100022500-A1 | Macrocyclic Lactams and Pharmaceutical Use Thereof | RPS11, MRPL21, RPS4Y1 | ALDH1A1 4236/4885L3MBTL1 4378/4885KMT2A 3031/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.