Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.70 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.70 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.70 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.67 |
| ▸ | TSHR | P16473 | 1/20 | 0.67 |
| ▸ | MC4R | P32245 | 1/20 | 0.67 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.67 |
| ▸ | MC3R | P41968 | 1/20 | 0.67 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.46 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5261595 | 0.85 | KMT2A (0.58) | KDM4ENAPRTHCAR2ADORA3TSHR | |
| SCHEMBL6765693 | 0.84 | KDM4E (0.57) | KDM4ENAPRTHCAR2ADORA3TSHR | |
| SCHEMBL7618500 | 0.84 | KDM4E (0.70) | KDM4ENAPRTHCAR2ADORA3TSHR | |
| SCHEMBL2536804 | 0.82 | — | — | |
| Pyrazinoic Acid SCHEMBL29651929 | 0.82 | — | — | |
| Pyrazinoic Acid SCHEMBL23757 | 0.82 | — | — | |
| SCHEMBL30593013 | 0.81 | KMT2A (0.63) | KDM4ENAPRTHCAR2ADORA3TSHR | |
| SCHEMBL4019791 | 0.81 | KMT2A (0.63) | KDM4ENAPRTHCAR2ADORA3TSHR | |
| Pyrazinamide SCHEMBL18364989 | 0.80 | — | — | |
| Pyrazinoic Acid SCHEMBL6631652 | 0.80 | KDM4E (0.95) | KDM4ENAPRTHCAR2ADORA3TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 328 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109336887-A | A kind of benzimidazole and chiral heterocycle class compound and its preparation method and application | 中山大学 | 2019-02-15 | — | — | CN | claimed |
| CN-107108528-A | The manufacture method of dihydro pyrazine ketone derivatives | 旭硝子株式会社 | 2017-08-29 | — | — | CN | claimed |
| CN-105622422-A | Bromohexahydro indanone compound and preparation method and application thereof | UNIV NANKAI | 2016-06-01 | — | — | CN | claimed |
| CN-103998042-A | Use of inhibitors of the activity or function of PI3K | NOVARTIS AG | 2014-08-20 | — | — | CN | claimed |
| CN-103906733-A | TRMP8 antagonists and their use in treatments | AMGEN INC | 2014-07-02 | — | — | CN | claimed |
| CN-103764145-A | Isoxazolines as therapeutic agents | ABBOTT LAB | 2014-04-30 | — | — | CN | claimed |
| CN-103232448-A | 4, 5-dihydro thiazole alcoholic ester derivative containing 4-methyl-1, 2, 3-thiadiazole and preparation method and application thereof | UNIV NANKAI | 2013-08-07 | — | — | CN | claimed |
| CN-103214474-A | 5-methyl-1,2,3-thiadiazole derivatives containing 4,5-dihydrothiazole alcohol acid esters and preparation methods and application thereof | UNIV NANKAI | 2013-07-24 | — | — | CN | claimed |
| CN-103214476-A | Formamidine derivatives containing 4-methyl-1,2,3-thiadiazole, and preparation methods and uses | UNIV NANKAI | 2013-07-24 | — | — | CN | claimed |
| CN-103214432-A | 5-methyl-1,2,3-thiadiazole based alpha-(substituted)oxyamide derivatives and preparation methods and application thereof | UNIV NANKAI | 2013-07-24 | — | — | CN | claimed |
| CN-1351593-A | Substituted polycyclic aryl and heteroaryl pyrymidinones useful as anticoagulants agents | PHARMACIA CO (US) | 2002-05-29 | — | — | CN | claimed |
| CN-1351595-A | Substituted polycyclic aryl and heteroaryl pyrazinones useful for selective inhibition of the coagulation cascade | PHARMACIA CO (US) | 2002-05-29 | — | — | CN | claimed |
| CN-1344268-A | Use of imidazo [1,5-a]pyrido[3,2-e]-pyrazinones as medicaments | DRESDEN ARZNEIMITTEL (DE) | 2002-04-10 | — | — | CN | claimed |
| CN-1297352-A | Use of organophosphorous compounds for the therapeutic and prophylactic treatment of infections | HASSAN JOMAA (DE) | 2001-05-30 | — | — | CN | claimed |
| CN-1286254-A | Aromatic amino ethers as analgesic agents | ZENECA LTD (GB) | 2001-03-07 | — | — | CN | claimed |
| CN-1058968-C | Novel pyrido [3,2-e] pyrazinones with anti-asthmatic action and processes for their manufacture | ASTA MEDICA AG (DE) | 2000-11-29 | — | — | CN | claimed |
| CN-1154106-A | Aromatic amino ethers as analgesic agents | ZENECA LTD (GB) | 1997-07-09 | — | — | CN | claimed |
| CN-1140173-A | Novel pyrido [3,2-e] pyrazinones with anti-asthmatic action and processes for their manufacture | ASTA MEDICA AG (DE) | 1997-01-15 | — | — | CN | claimed |
| CN-1065270-A | The thieno-pyran derivate method of preparation enantiomer-pure | ORTHO PHARMA CORP (US) | 1992-10-14 | — | — | CN | claimed |
| CN-1031378-A | Antimicrobial compounds | ICI PLC (GB) | 1989-03-01 | — | — | CN | claimed |