Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 5/20 | 1.00 |
| ▸ | LMNA | P02545 | 4/20 | 1.00 |
| ▸ | PPM1B | O75688 | 4/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 1.00 |
| ▸ | GMNN | O75496 | 3/20 | 1.00 |
| ▸ | TFPI2 | P48307 | 3/20 | 1.00 |
| ▸ | PMP22 | Q01453 | 3/20 | 1.00 |
| ▸ | NFKB1 | P19838 | 3/20 | 1.00 |
| ▸ | THPO | P40225 | 3/20 | 1.00 |
| ▸ | RAB9A | P51151 | 3/20 | 1.00 |
| ▸ | PPP1CC | P36873 | 2/20 | 1.00 |
| ▸ | PPP5C | P53041 | 2/20 | 1.00 |
| ▸ | PPP1CA | P62136 | 2/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 1/20 | 1.00 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Demethyl-Cantharidin SCHEMBL177729 | 1.00 | TP53 (1.00) | TP53LMNAPPM1BSMN1; SMN2KDM4E | |
| Norcantharidin SCHEMBL29380910 | 1.00 | TP53 (1.00) | TP53LMNAPPM1BSMN1; SMN2KDM4E | |
| Demethyl-Cantharidin SCHEMBL9675442 | 1.00 | TP53 (1.00) | TP53LMNAPPM1BSMN1; SMN2KDM4E | |
| Demethyl-Cantharidin SCHEMBL3195020 | 1.00 | TP53 (1.00) | TP53LMNAPPM1BSMN1; SMN2KDM4E | |
| Demethyl-Cantharidin SCHEMBL19318920 | 1.00 | TP53 (1.00) | TP53LMNAPPM1BSMN1; SMN2KDM4E | |
| Demethyl-Cantharidin SCHEMBL6432892 | 1.00 | TP53 (1.00) | TP53LMNAPPM1BSMN1; SMN2KDM4E | |
| Demethyl-Cantharidin SCHEMBL9906842 | 1.00 | TP53 (1.00) | TP53LMNAPPM1BSMN1; SMN2KDM4E | |
| SCHEMBL16938608 | 0.84 | KDM4E (0.71) | TP53LMNAPPM1BSMN1; SMN2KDM4E | |
| SCHEMBL17695028 | 0.84 | KDM4E (0.71) | TP53LMNAPPM1BSMN1; SMN2KDM4E | |
| SCHEMBL12599313 | 0.74 | KDM4E (0.57) | TP53LMNAPPM1BSMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 78 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118791500-A | 7-Oxabicyclo [2.2.1] heptane-2, 3-dicarboxylic acid derivative and preparation method and application thereof | 中国药科大学 | 2024-10-18 | — | — | CN | disclosed |
| CN-113956236-B | Phthalimide compound and application thereof | 中国医学科学院药物研究所 | 2023-01-06 | — | — | CN | disclosed |
| CN-113929662-B | Succinimide or maleimide compound and use thereof | 中国医学科学院药物研究所 | 2023-01-06 | — | — | CN | disclosed |
| CN-109867661-B | Amide compounds for regulating WNT signal pathway and application thereof | 中国医学科学院药物研究所 | 2022-07-19 | — | — | CN | disclosed |
| CN-113956236-A | Phthalimide compound and application thereof | 中国医学科学院药物研究所 | 2022-01-21 | — | — | CN | disclosed |
| CN-113929662-A | Succinimide or maleimide compound and use thereof | 中国医学科学院药物研究所 | 2022-01-14 | — | — | CN | disclosed |
| US-10399993-B2 | Oxabicycloheptanes and oxabicycloheptenes, their preparation and use | LIXTE BIOTECHNOLOGY, INC. (US) | 2019-09-03 | — | — | US | disclosed |
| US-10023587-B2 | Oxabicycloheptanes and oxabicycloheptenes, their preparation and use | LIXTE BIOTECHNOLOGY, INC. (US) | 2018-07-17 | — | — | US | disclosed |
| US-10023587-B2 | Oxabicycloheptanes and oxabicycloheptenes, their preparation and use | LIXTE BIOTECHNOLOGY, INC. (US) | 2018-07-17 | — | — | US | disclosed |
| US-9994584-B2 | Process of synthesizing 3-(4-methylpiperazine-1-carbonyl)-7-oxabicyclo[2.2.1] heptane-2-carboxylic acid | LIXTE BIOTECHNOLOGY, INC. (US) | 2018-06-12 | — | — | US | disclosed |
| WO-2002000617-A2 | SELECTIVE ANDROGEN RECEPTOR MODULATORS AND METHODS FOR THEIR IDENTIFICATION, DESIGN AND USE | BRISTOL-MYERS SQUIBB COMPANY (US) | 2002-01-03 | — | — | WO | disclosed |
| US-5618946-A | 7-oxabicycloheptane carboxylic acid prostaglandin analog intermediates useful in the preparation of anti-thrombotic and anti-vasospastic compounds and method for preparing same | BRISTOL-MYERS SQUIBB COMPANY (US) | 1997-04-08 | — | — | US | disclosed |
| US-5539130-A | CHEMICAL CONDENSATION FOLLOWED BY CATALYTIC HYDROGENATION | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-07-23 | — | — | US | disclosed |
| US-5512690-A | 7-oxabicycloheptane carboxylic acid prostaglandin analog intermediates useful in the preparation of anti-thrombotic and anti-basopastic compounds and method for preparing same | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-04-30 | — | — | US | disclosed |
| US-5508445-A | FORMING A CHEMICAL INTERMEDIATE ALDEHYDE, STARTING AN AMINE AND AN ANHYDRIDE TO FORM AN IMIDE, THEN GRIGNARD REACTION, REACTING WITH A REDUCING AGENT | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-04-16 | — | — | US | disclosed |
| US-5436347-A | Benzaldehyde intermediates useful in the preparation of 7-oxabicycloheptane carboxylic acid prostaglandin analog anti-thrombotic and anti-vasospastic compounds and method for preparing same | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-07-25 | — | — | US | disclosed |
| US-5399725-A | Forming alcohol-amides by reacting a 7-oxabicycloheptane imide with a 2-/2-metallated phenyl/-1,3-dioxolane /metal is lithium or magnesium bromide/ and reducing the product | BRISTOL-MYERS SQUIBB CO. (US) | 1995-03-21 | — | — | US | disclosed |
| EP-0626384-A1 | 7-Oxabicycloheptane carboxylic acid prostaglandin analog intermediates useful in the preparation of antithrombotic and anti-vasospastic compounds and method for preparing same | BRISTOL-MYERS SQUIBB COMPANY (US) | 1994-11-30 | — | — | EP | disclosed |
| US-5332840-A | Acylation an anhydride and reaction with oxazolidine to form benzaldehyde | BRISTOL-MYERS SQUIBB COMPANY (US) | 1994-07-26 | — | — | US | disclosed |
| US-4524151-A | 7-Oxabicycloheptane thio ethers useful as cardiovascular agents | E. R. SQUIBB & SONS, INC. (US) | 1985-06-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10399993-B2 | Oxabicycloheptanes and oxabicycloheptenes, their preparation and use | HCCS, OXA1L, OTC | TP53 75/4885LMNA 2628/4885PPM1B 3573/4885 |
| US-10023587-B2 | Oxabicycloheptanes and oxabicycloheptenes, their preparation and use | HCCS, OXA1L, OTC | TP53 75/4885LMNA 2628/4885PPM1B 3573/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.