Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNB2 | O95067 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.37 |
| ▸ | ELANE | P08246 | 4/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.35 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.35 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.35 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.35 |
| ▸ | TSPO | P30536 | 1/20 | 0.35 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3200237 | 0.83 | CDK1 (0.46) | CCNB2CDK1CCNB1GSK3BCCNB3 | |
| SCHEMBL3197264 | 0.83 | CDK1 (0.47) | CCNB2CDK1CCNB1GSK3BCCNB3 | |
| SCHEMBL1920073 | 0.81 | CDK1 (0.47) | CCNB2CDK1CCNB1GSK3BCCNB3 | |
| SCHEMBL3460696 | 0.80 | CCNB2 (0.42) | CCNB2CDK1CCNB1GSK3BCCNB3 | |
| SCHEMBL3461451 | 0.79 | CCNB2 (0.41) | CCNB2CDK1CCNB1GSK3BCCNB3 | |
| SCHEMBL409607 | 0.79 | CDK1 (0.54) | CCNB2CDK1CCNB1GSK3BCCNB3 | |
| SCHEMBL3461221 | 0.78 | CCNB2 (0.41) | CCNB2CDK1CCNB1GSK3BCCNB3 | |
| SCHEMBL1920584 | 0.76 | CDK1 (0.40) | CCNB2CDK1CCNB1GSK3BCCNB3 | |
| SCHEMBL2186140 | 0.75 | CCNB2 (0.49) | CCNB2CDK1CCNB1GSK3BCCNB3 | |
| SCHEMBL3194957 | 0.75 | HSD17B2 (0.41) | ALDH1A1CACNA1BGABRG2GABRB3GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7666897-B2 | Analogs of indole-3-carbinol metabolites as chemotherapeutic and chemopreventive agents | SRI INTERNATIONAL (US) | 2010-02-23 | — | — | US | disclosed |
| US-7666897-B2 | Analogs of indole-3-carbinol metabolites as chemotherapeutic and chemopreventive agents | SRI INTERNATIONAL (US) | 2010-02-23 | — | — | US | disclosed |
| US-7666897-B2 | Analogs of indole-3-carbinol metabolites as chemotherapeutic and chemopreventive agents | SRI INTERNATIONAL (US) | 2010-02-23 | — | — | US | disclosed |
| US-20090023796-A1 | Analogs of Indole-3-Carbinol Metabolites as Chemotherapeutic and Chemopreventive Agents | SRI INTERNATIONAL (US) | 2009-01-22 | — | — | US | disclosed |
| US-20090023796-A1 | Analogs of Indole-3-Carbinol Metabolites as Chemotherapeutic and Chemopreventive Agents | SRI INTERNATIONAL (US) | 2009-01-22 | — | — | US | disclosed |
| US-20090023796-A1 | Analogs of Indole-3-Carbinol Metabolites as Chemotherapeutic and Chemopreventive Agents | SRI INTERNATIONAL (US) | 2009-01-22 | — | — | US | disclosed |
| EP-1530572-B1 | ANALOGS OF INDOLE-3-CARBINOL METABOLITES AS CHEMOTHERAPEUTIC AND CHEMOPREVENTIVE AGENTS | STANFORD RES INST INT (US) | 2008-10-15 | — | — | EP | disclosed |
| US-7429610-B2 | Analogs of indole-3-carbinol metabolites as chemotherapeutic and chemopreventive agents | SRI INTERNATIONAL (US) | 2008-09-30 | — | — | US | disclosed |
| US-7429610-B2 | Analogs of indole-3-carbinol metabolites as chemotherapeutic and chemopreventive agents | SRI INTERNATIONAL (US) | 2008-09-30 | — | — | US | disclosed |
| US-7429610-B2 | Analogs of indole-3-carbinol metabolites as chemotherapeutic and chemopreventive agents | SRI INTERNATIONAL (US) | 2008-09-30 | — | — | US | disclosed |
| US-7078427-B2 | Analogs of indole-3-carbinol metabolites as chemotherapeutic and chemopreventive agents | SRI INTERNATIONAL (US) | 2006-07-18 | — | — | US | disclosed |
| US-20060128785-A1 | Analogs of indole-3-carbinol metabolites as chemotherapeutic and chemopreventive agents | SRI INTERNATIONAL (US) | 2006-06-15 | — | — | US | disclosed |
| EP-1623985-A2 | Analogs of indole-3-carbinol metabolites as chemotherapeutic and chemopreventative agents | Sri International (US) | 2006-02-08 | — | — | EP | disclosed |
| US-6800655-B2 | Analogs of indole-3-carbinol metabolites as chemotherapeutic and chemopreventive agents | SRI INTERNATIONAL | 2004-10-05 | — | — | US | disclosed |
| US-20040157906-A1 | Analogs of indole-3-carbinol metabolites as chemotherapeutic and chemopreventive agents | JONG LING (US) | 2004-08-12 | — | — | US | disclosed |
| US-20040043965-A1 | Analogs of indole-3-carbinol metabolites as chemotherapeutic and chemopreventive agents | SRI INTERNATIONAL | 2004-03-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060128785-A1 | Analogs of indole-3-carbinol metabolites as chemotherapeutic and chemopreventive agents | IDO1, CCND3, FOXM1 | CCNB2 79/4885CDK1 147/4885CCNB1 26/4885 |
| US-20090023796-A1 | Analogs of Indole-3-Carbinol Metabolites as Chemotherapeutic and Chemopreventive Agents | IDO1, CCND3, CCNA1 | CCNB2 74/4885CDK1 208/4885CCNB1 26/4885 |
| US-20040043965-A1 | Analogs of indole-3-carbinol metabolites as chemotherapeutic and chemopreventive agents | IDO1, IDO2, TPH1 | CCNB2 240/4885CDK1 257/4885CCNB1 76/4885 |
| US-20040157906-A1 | Analogs of indole-3-carbinol metabolites as chemotherapeutic and chemopreventive agents | IDO1, IDO2, TPH1 | CCNB2 240/4885CDK1 257/4885CCNB1 76/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.