Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | CA1 | P00915 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | CA7 | P43166 | 2/20 | 0.38 |
| ▸ | CA9 | Q16790 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.35 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | NOS3 | P29474 | 1/20 | 0.32 |
| ▸ | NOS1 | P29475 | 1/20 | 0.32 |
| ▸ | NOS2 | P35228 | 1/20 | 0.32 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10825590 | 0.94 | TSHR (0.47) | TSHRACHEALDH1A1CA1CA2 | |
| Hydrochloric Acid SCHEMBL5908722 | 0.94 | TSHR (0.47) | TSHRACHEALDH1A1CA1CA2 | |
| Hydrochloric Acid SCHEMBL30217238 | 0.94 | TSHR (0.47) | TSHRACHEALDH1A1CA1CA2 | |
| Hydrochloric Acid SCHEMBL105623 | 0.94 | TSHR (0.47) | TSHRACHEALDH1A1CA1CA2 | |
| SCHEMBL3127305 | 0.94 | TSHR (0.53) | TSHRACHEALDH1A1CA1CA2 | |
| SCHEMBL29357701 | 0.94 | TSHR (0.53) | TSHRACHEALDH1A1CA1CA2 | |
| SCHEMBL4480 | 0.94 | TSHR (0.53) | TSHRACHEALDH1A1CA1CA2 | |
| Hydrochloric Acid SCHEMBL2857411 | 0.92 | TSHR (0.50) | TSHRACHEALDH1A1CA1CA2 | |
| Bromide SCHEMBL3688252 | 0.92 | TSHR (0.50) | TSHRACHEALDH1A1CA1CA2 | |
| SCHEMBL2502467 | 0.92 | TSHR (0.50) | TSHRACHEALDH1A1CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10300473-B2 | Catalytic composition comprising nickel and a ligand of the phosphane complexed with nickel type, and use thereof in a olefin oligomerisation method | IFP Energies Nouvelles (FR) | 2019-05-28 | — | — | US | claimed |
| US-20180221861-A1 | NOVEL CATALYTIC COMPOSITION COMPRISING NICKEL AND A LIGAND OF THE PHOSPHANE COMPLEXED WITH NICKEL TYPE, AND USE THEREOF IN A OLEFIN OLIGOMERISATION METHOD | IFP Energies Nouvelles (FR) | 2018-08-09 | — | — | US | claimed |
| US-10300473-B2 | Catalytic composition comprising nickel and a ligand of the phosphane complexed with nickel type, and use thereof in a olefin oligomerisation method | IFP Energies Nouvelles (FR) | 2019-05-28 | — | — | US | disclosed |
| US-20180221861-A1 | NOVEL CATALYTIC COMPOSITION COMPRISING NICKEL AND A LIGAND OF THE PHOSPHANE COMPLEXED WITH NICKEL TYPE, AND USE THEREOF IN A OLEFIN OLIGOMERISATION METHOD | IFP Energies Nouvelles (FR) | 2018-08-09 | — | — | US | disclosed |
| US-7675587-B2 | Polarizing plate and process for producing the same | JSR CORPORATION (JP) | 2010-03-09 | — | — | US | disclosed |
| US-7049220-B2 | Method of forming cavity between multilayered wirings | JSR CORPORATION (JP) | 2006-05-23 | — | — | US | disclosed |
| EP-1626294-A2 | Polarizing plate and process for producing the same | JSR Corporation (JP) | 2006-02-15 | — | — | EP | disclosed |
| US-20060027322-A1 | Polarizing plate and process for producing the same | JSR CORPORATION (JP) | 2006-02-09 | — | — | US | disclosed |
| US-20040132243-A1 | Method of forming cavity between multilayered wirings | JSR CORPORATION (JP) | 2004-07-08 | — | — | US | disclosed |
| EP-1416528-A2 | Method of forming cavity between multilayered wirings | JSR Corporation (JP) | 2004-05-06 | — | — | EP | disclosed |