Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | F2 | P00734 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | SRC | P12931 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.43 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.43 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | CES1 | P23141 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1536367 | 1.00 | TSHR (0.59) | TSHRF2LMNACA1CA2 | |
| SCHEMBL1536368 | 1.00 | TSHR (0.59) | TSHRF2LMNACA1CA2 | |
| SCHEMBL16403663 | 0.88 | TSHR (0.59) | TSHRF2LMNASLC6A3SRC | |
| SCHEMBL14852715 | 0.86 | TSHR (0.57) | TSHRF2LMNARAB9AMAPT | |
| SCHEMBL1137903 | 0.86 | TSHR (0.57) | TSHRF2LMNASLC6A3SRC | |
| SCHEMBL7073576 | 0.84 | TSHR (0.55) | TSHRF2LMNASLC6A3SRC | |
| SCHEMBL15880803 | 0.84 | TSHR (0.55) | TSHRF2LMNASLC6A3SRC | |
| SCHEMBL28732348 | 0.84 | TDP1 (0.59) | LMNARAB9AMAPTNPC1KDM4E | |
| SCHEMBL11875080 | 0.84 | CA1 (0.59) | TSHRLMNACA1CA2MAPT | |
| SCHEMBL13183413 | 0.83 | TSHR (0.50) | TSHRF2LMNASLC6A3SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115350099-A | Emulsification method and application of oil-in-water type sunscreen composition | 广州栋方生物科技股份有限公司 | 2022-11-18 | — | — | CN | claimed |
| CN-115350099-A | Emulsification method and application of oil-in-water type sunscreen composition | 广州栋方生物科技股份有限公司 | 2022-11-18 | — | — | CN | disclosed |
| EP-3236777-A1 | TASTE MODIFYING COMPOSITIONS | Celanese Sales Germany GmbH (DE) | 2017-11-01 | — | — | EP | disclosed |
| EP-3236778-A1 | TASTE MODIFYING COMPOSITIONS | Celanese Sales Germany GmbH (DE) | 2017-11-01 | — | — | EP | disclosed |
| EP-3236776-A1 | TASTE MODIFYING COMPOSITIONS | Celanese Sales Germany GmbH (DE) | 2017-11-01 | — | — | EP | disclosed |
| US-20160183576-A1 | TASTE MODIFYING COMPOSITIONS | CELANESE SALES GERMANY GMBH (DE) | 2016-06-30 | — | — | US | disclosed |
| WO-2016103163-A1 | TASTE MODIFYING COMPOSITIONS | CELANESE SALES GERMANY GMBH (DE) | 2016-06-30 | — | — | WO | disclosed |
| US-20160183578-A1 | TASTE MODIFYING COMPOSITIONS | CELANESE SALES GERMANY GMBH (DE) | 2016-06-30 | — | — | US | disclosed |
| US-20160183579-A1 | TASTE MODIFYING COMPOSITIONS | CELANESE SALES GERMANY GMBH (DE) | 2016-06-30 | — | — | US | disclosed |
| US-20160183580-A1 | TASTE MODIFYING COMPOSITIONS | CELANESE SALES GERMANY GMBH (DE) | 2016-06-30 | — | — | US | disclosed |
| WO-2016103183-A1 | TASTE MODIFYING COMPOSITIONS | CELANESE SALES GERMANY GMBH (DE) | 2016-06-30 | — | — | WO | disclosed |
| WO-2016103182-A1 | TASTE MODIFYING COMPOSITIONS | CELANESE SALES GERMANY GMBH (DE) | 2016-06-30 | — | — | WO | disclosed |
| WO-2016103184-A1 | TASTE MODIFYING COMPOSITIONS | CELANESE SALES GERMANY GMBH (DE) | 2016-06-30 | — | — | WO | disclosed |
| US-20150191607-A1 | Anti-fouling Paints and Coatings | REACTIVE SURFACES, LTD (US) | 2015-07-09 | — | — | US | disclosed |
| US-20100075970-A1 | INHIBITORS OF AKT ACTIVITY | MERCK SHARP & DOHME CORP. | 2010-03-25 | — | — | US | disclosed |
| US-7655649-B2 | Cancer; N,N-dimethyl-5-phenyl-6-(4-{[4-(5-pyridin-2-yl-1H-pyrazol-3-yl)piperidin-1-yl]methyl}phenyl) pyridazin-3-amine;; serine/threonine kinase (Akt) suppression; increased cellular potency or solubility, enhanced pharmacokinetic properties | MERCK SHARP & DOHME CORP. (US) | 2010-02-02 | — | — | US | disclosed |
| EP-1737843-A4 | INHIBITORS OF AKT ACTIVITY | MERCK & CO INC (US) | 2009-01-28 | — | — | EP | disclosed |
| US-20080280889-A1 | Inhibitors of Akt Activity | MERCK SHARP & DOHME CORP. | 2008-11-13 | — | — | US | disclosed |
| EP-1737843-A1 | INHIBITORS OF AKT ACTIVITY | Merck & Co., Inc. (US) | 2007-01-03 | — | — | EP | disclosed |
| WO-2005100344-A1 | INHIBITORS OF AKT ACTIVITY | MERCK & CO., INC. (US) | 2005-10-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100075970-A1 | INHIBITORS OF AKT ACTIVITY | PIK3CA, AKT2, AKT1 | TSHR 4081/4885F2 4608/4885LMNA 4289/4885 |
| US-20080280889-A1 | Inhibitors of Akt Activity | AKT2, PIK3CA, AKT1 | TSHR 4214/4885F2 4648/4885LMNA 4294/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.