Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.36 |
| ▸ | BRAF | P15056 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.34 |
| ▸ | KDM6B | O15054 | 1/20 | 0.33 |
| ▸ | KDM5C | P41229 | 1/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.33 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.33 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.31 |
| ▸ | AXL | P30530 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 4-Imidazolecarboxylic Acid SCHEMBL13733596 | 0.82 | KDM4E (0.45) | KDM4EALDH1A1NPC1RAB9AMAPK1 | |
| SCHEMBL69204 | 0.82 | — | — | |
| SCHEMBL262815 | 0.75 | — | — | |
| Trifluoroacetic Acid SCHEMBL30271697 | 0.75 | MAPK1 (0.40) | KDM4EALDH1A1NPC1RAB9AMAPK1 | |
| Biphenyl SCHEMBL27647991 | 0.75 | AXL (0.48) | ALDH1A1NPC1RAB9AMAPK1NR4A2 | |
| Methyl Alcohol SCHEMBL27647148 | 0.75 | NPC1 (0.52) | KDM4EALDH1A1NPC1RAB9ABRAF | |
| SCHEMBL41312 | 0.74 | — | — | |
| Hydrochloric Acid SCHEMBL10511789 | 0.73 | — | — | |
| Phosphine SCHEMBL14798918 | 0.73 | — | — | |
| Bromide SCHEMBL31019391 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7666893-B2 | Method for treatment of neurodegenerative disorders | MEDDEV INC. (US) | 2010-02-23 | — | — | US | disclosed |
| US-20070276021-A1 | Method for treatment of neurodegenerative disorders | MEDDEV INC. | 2007-11-29 | — | — | US | disclosed |
| EP-1859800-A1 | Medicament comprising alkyl esters of imidazole carboxylic acid for the treatment of neurodegenerative disorders | Delack, Elaine A. (US) | 2007-11-28 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070276021-A1 | Method for treatment of neurodegenerative disorders | PMP22, OTC, IPO4 | KDM4E 1415/4885ALDH1A1 2332/4885NPC1 412/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.