Sugi Predict

Sugi Predict / Targets / IPO4

IPO4

Importin-4 · Q8TEX9 · IPO4 on Sugi Atlas →

0 patent compounds predicted against IPO4, 0 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours

Clinical trials — most relevant to IPO4 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Hydroxychloroquine and Ivermectin for the Treatment of COVID-19 Infection PHASE3COMPLETED
Ivermectin and Nitazoxanide Combination Therapy for COVID-19 PHASE2/PHASE3UNKNOWN
A Phase Ib/II Clinical Study Evaluating the Safety and Efficacy of Tislelizumab in Combination With Golidocitinib and Selinexor for the Treatment of R/R NKTCL PHASE1/PHASE2RECRUITING
Efficacy of Ivermectin in COVID-19 PHASE1/PHASE2COMPLETED
Melpida: Recombinant Adeno-associated Virus (serotype 9) Encoding a Codon Optimized Human AP4M1 Transgene (hAP4M1opt) PHASE1/PHASE2RECRUITING
Selinexor With ICE Chemotherapy in Secondary Central Nervous System Involving B-cell Non-Hodgkin Lymphoma PHASE1/PHASE2RECRUITING
Intra-Testicular Transplantation of Autologous Stem Cells for Treatment of Non-Obstructive Azoospermia Male Infertility. PHASE1/PHASE2UNKNOWN
Role of the Nuclear Pore Component RANBP2 in Inflammatory Responses to Viral Infections nanCOMPLETED
A Clinical Study on the Efficacy and Safety of Methotrexate (MTX) or Thiotepa (for MTX Intolerance) or Temozolomide (TMZ) Combined With Orelabrutinib and Selinexor in Relapsed/Refractory Primary or Secondary Central Nervous System Lymphoma（SELINA） nanRECRUITING
Prognostic Value of Protein IMP3 Expression in Cervical Cancer nanCOMPLETED
Plasma Triglyceride Lipolysis in Multifactorial Chylomicronemia nanCOMPLETED
Pulmonary Hypertension--Mechanisms and Family Registry nanCOMPLETED
Steroid Treatment of Idiopathic Nephrotic Syndrome nanCOMPLETED
Inter-regional Project of the Great Western Exploration Approach for Exome Molecular Causes Severe Intellectual Disability Isolated or Syndromic nanCOMPLETED
Genetic Investigation of Solid Tumors Cohort nanCOMPLETED
MEHMO Natural History and Biomarkers nanRECRUITING
Clinical and Genetic Analysis in Congenital Hypothyroidism Due to Thyroid Dysgenesis. nanCOMPLETED
Autophagy in Systemic Lupus Erythematosus nanUNKNOWN
Biomarker for Sanfilippo Type A-B-C-D Disease (BioSanfilippo) nanWITHDRAWN
Dried Fruit and Postprandial Glycemia Trial nanUNKNOWN
Genetic Epidemiology of Sarcoidosis nanCOMPLETED
Genetic Analysis of Gray Platelet Syndrome nanCOMPLETED
Differential Gene Expression of Liver Tissue and Blood From Individuals With Chronic Viral Hepatitis nanUNKNOWN
Linkage Study in Familial Pulmonary Fibrosis nanCOMPLETED
Genetic Studies Spermatogenic Failure nanCOMPLETED
Finding Genes With NGS Techniques in Whom Mutations Cause Neurological Diseases nanUNKNOWN
Diagnosis of Primary Ciliary Dyskinesia nanCOMPLETED
LINC00511/miR-185-3p Axis and miR-301a-3p Markers for Breast Cancer Diagnosis nanCOMPLETED
Study of Constitutional Platelet Disease nanUNKNOWN
New Genes Involved in Molecular Etiology of Rett Syndrome Through DNA Microarray Comparative Genomic Hybridization nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a IPO4 binder may also engage these)

ProteinNameSimilarity
Q8VI75 — 0.997 Q8VI75 →
Q9R0L4 — 0.985 Q9R0L4 →
O75155 — 0.981 O75155 →
Q86Y56 — 0.981 Q86Y56 →
Q6ZQ73 — 0.980 Q6ZQ73 →
Q8BKC5 — 0.978 Q8BKC5 →
IPO5 Importin-5 0.975 landscape →
Q9WV76 — 0.975 Q9WV76 →
Q91YE6 — 0.972 Q91YE6 →
E1BP36 — 0.972 E1BP36 →
IPO9 Importin-9 0.971 landscape →
Q7TMY7 — 0.971 Q7TMY7 →
Q0V9L1 — 0.970 Q0V9L1 →
A5WW24 — 0.969 A5WW24 →
E0CZ22 — 0.969 E0CZ22 →
Q8BIV3 — 0.969 Q8BIV3 →
O60518 — 0.969 O60518 →
A0JMW2 — 0.968 A0JMW2 →
B9EJR8 — 0.968 B9EJR8 →
Q9Y6B7 — 0.968 Q9Y6B7 →
Q8NDA8 — 0.968 Q8NDA8 →
MMS19 MMS19 nucleotide excision repair protein homolog 0.967 landscape →
Q9D071 — 0.967 Q9D071 →
Q5SPJ8 — 0.967 Q5SPJ8 →
Q5ZKD5 — 0.966 Q5ZKD5 →
A4IG72 — 0.966 A4IG72 →
Q5NVK5 — 0.966 Q5NVK5 →
Q6AY79 — 0.966 Q6AY79 →
Q6PDS3 — 0.965 Q6PDS3 →
A7MB11 — 0.965 A7MB11 →