Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.30 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14902699 | 1.00 | MEN1 (0.31) | MEN1KMT2AGAAHTTCYP17A1 | |
| SCHEMBL14892090 | 0.82 | CYP17A1 (0.30) | CYP17A1CYP19A1 | |
| SCHEMBL319061 | 0.82 | CYP17A1 (0.30) | CYP17A1CYP19A1 | |
| SCHEMBL319918 | 0.82 | CYP17A1 (0.30) | CYP17A1CYP19A1 | |
| SCHEMBL320018 | 0.82 | MEN1 (0.36) | MEN1KMT2AGAAHTT | |
| SCHEMBL10278534 | 0.82 | MEN1 (0.36) | MEN1KMT2AGAAHTT | |
| SCHEMBL14902777 | 0.80 | MEN1 (0.30) | MEN1KMT2A | |
| SCHEMBL319390 | 0.80 | MEN1 (0.32) | MEN1KMT2AGAAHTT | |
| SCHEMBL14902778 | 0.79 | — | — | |
| SCHEMBL319330 | 0.78 | MEN1 (0.31) | MEN1KMT2AGAAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2590968-A1 | CYCLIC ETHER COMPOUNDS USEFUL AS KINASE INHIBITORS | Novartis AG (CH) | 2013-05-15 | — | — | EP | disclosed |
| WO-2012004217-A1 | CYCLIC ETHER COMPOUNDS USEFUL AS KINASE INHIBITORS | NOVARTIS AG (CH) | 2012-01-12 | — | — | WO | disclosed |