Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 7/20 | 0.83 |
| ▸ | ESR1 | P03372 | 12/20 | 0.61 |
| ▸ | ESR2 | Q92731 | 12/20 | 0.61 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13419394 | 0.92 | APP (0.93) | APPESR1ESR2NPC1RAB9A | |
| SCHEMBL3181272 | 0.84 | APP (0.84) | APPESR1ESR2NPC1RAB9A | |
| SCHEMBL4002156 | 0.82 | APP (0.61) | APPESR1ESR2NPC1RAB9A | |
| SCHEMBL3200362 | 0.81 | APP (0.65) | APPNPC1RAB9A | |
| SCHEMBL13419359 | 0.80 | APP (0.93) | APPESR1ESR2NPC1RAB9A | |
| SCHEMBL3188802 | 0.79 | MAPT (0.59) | APPNPC1RAB9A | |
| SCHEMBL27090228 | 0.78 | ESR1 (0.96) | APPESR1ESR2NPC1RAB9A | |
| SCHEMBL2158317 | 0.77 | ESR1 (1.00) | APPESR1ESR2NPC1RAB9A | |
| SCHEMBL3187059 | 0.76 | ESR1 (0.68) | APPESR1ESR2NPC1RAB9A | |
| SCHEMBL21462332 | 0.76 | ESR1 (0.68) | APPESR1ESR2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101506201-A | Novel heteroaryl substituted benzoxazoles | ASTRAZENECA AB (SE) | 2009-08-12 | — | — | CN | claimed |
| EP-2035418-A1 | NOVEL HETEROARYL SUBSTITUTED BENZOXAZOLES | Astra Zeneca AB (SE) | 2009-03-18 | — | — | EP | claimed |
| US-20080027051-A1 | Novel Heteroaryl Substituted Benzoxazoles | ASTRAZENECA AB (SE) | 2008-01-31 | — | — | US | claimed |
| WO-2007149030-A1 | NOVEL HETEROARYL SUBSTITUTED BENZOXAZOLES | ASTRAZENECA AB (SE) | 2007-12-27 | — | — | WO | claimed |
| CN-101506201-B | Novel heteroaryl-substituted benzazoles derivatives | ASTRAZENECA AB | 2012-03-14 | — | — | CN | disclosed |
| US-7670591-B2 | Heteroaryl substituted benzoxazoles | ASTRAZENECA AB (SE) | 2010-03-02 | — | — | US | disclosed |
| US-7670591-B2 | Heteroaryl substituted benzoxazoles | ASTRAZENECA AB (SE) | 2010-03-02 | — | — | US | disclosed |
| US-7670591-B2 | Heteroaryl substituted benzoxazoles | ASTRAZENECA AB (SE) | 2010-03-02 | — | — | US | disclosed |
| CN-101506201-A | Novel heteroaryl substituted benzoxazoles | ASTRAZENECA AB (SE) | 2009-08-12 | — | — | CN | disclosed |
| EP-2035418-A1 | NOVEL HETEROARYL SUBSTITUTED BENZOXAZOLES | Astra Zeneca AB (SE) | 2009-03-18 | — | — | EP | disclosed |
| US-20080027051-A1 | Novel Heteroaryl Substituted Benzoxazoles | ASTRAZENECA AB (SE) | 2008-01-31 | — | — | US | disclosed |
| US-20080027051-A1 | Novel Heteroaryl Substituted Benzoxazoles | ASTRAZENECA AB (SE) | 2008-01-31 | — | — | US | disclosed |
| US-20080027051-A1 | Novel Heteroaryl Substituted Benzoxazoles | ASTRAZENECA AB (SE) | 2008-01-31 | — | — | US | disclosed |
| WO-2007149030-A1 | NOVEL HETEROARYL SUBSTITUTED BENZOXAZOLES | ASTRAZENECA AB (SE) | 2007-12-27 | — | — | WO | disclosed |
| WO-2007149030-A1 | NOVEL HETEROARYL SUBSTITUTED BENZOXAZOLES | ASTRAZENECA AB (SE) | 2007-12-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080027051-A1 | Novel Heteroaryl Substituted Benzoxazoles | PSEN1, PSEN2, APP | APP 3/4885ESR1 3839/4885ESR2 3552/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.