Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.31 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL318829 | 0.80 | MEN1 (0.40) | KMT2AMEN1HTTGAAMAPT | |
| SCHEMBL319500 | 0.80 | OPRK1 (0.32) | KMT2AMEN1HTTGAA | |
| SCHEMBL14902734 | 0.75 | MEN1 (0.33) | KMT2AMEN1HTTGAA | |
| SCHEMBL14906115 | 0.75 | MEN1 (0.33) | KMT2AMEN1HTTGAACYP2C9 | |
| SCHEMBL1910760 | 0.73 | MEN1 (0.32) | KMT2AMEN1 | |
| SCHEMBL1911242 | 0.72 | MEN1 (0.33) | KMT2AMEN1 | |
| SCHEMBL10278859 | 0.72 | MEN1 (0.35) | KMT2AMEN1 | |
| SCHEMBL10278541 | 0.72 | MEN1 (0.30) | KMT2AMEN1 | |
| SCHEMBL319155 | 0.72 | MEN1 (0.30) | KMT2AMEN1 | |
| SCHEMBL325128 | 0.71 | MEN1 (0.44) | KMT2AMEN1HTTGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2590968-A1 | CYCLIC ETHER COMPOUNDS USEFUL AS KINASE INHIBITORS | Novartis AG (CH) | 2013-05-15 | — | — | EP | disclosed |
| WO-2012004217-A1 | CYCLIC ETHER COMPOUNDS USEFUL AS KINASE INHIBITORS | NOVARTIS AG (CH) | 2012-01-12 | — | — | WO | disclosed |