Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Adenosine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY2 | P41231 | 4/20 | 0.65 |
| ▸ | P2RY4 | P51582 | 2/20 | 0.65 |
| ▸ | P2RY6 | Q15077 | 2/20 | 0.65 |
| ▸ | DTYMK | P23919 | 4/20 | 0.64 |
| ▸ | P2RY1 | P47900 | 6/20 | 0.63 |
| ▸ | P2RX1 | P51575 | 2/20 | 0.63 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.63 |
| ▸ | P2RX2 | Q9UBL9 | 2/20 | 0.63 |
| ▸ | SRC | P12931 | 1/20 | 0.63 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.63 |
| ▸ | MACROD2 | A1Z1Q3 | 1/20 | 0.62 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.62 |
| ▸ | MACROD1 | Q9BQ69 | 1/20 | 0.62 |
| ▸ | TRPM2 | O94759 | 1/20 | 0.62 |
| ▸ | RNASEL | Q05823 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13421163 | 0.95 | P2RY2 (0.71) | P2RY2P2RY4P2RY6DTYMKP2RY1 | |
| SCHEMBL26031180 | 0.95 | P2RY2 (0.71) | P2RY2P2RY4P2RY6DTYMKP2RY1 | |
| Adenosine SCHEMBL3205128 | 0.91 | P2RY1 (0.74) | P2RY2DTYMKP2RY1P2RX1P2RX3 | |
| SCHEMBL16310667 | 0.88 | RNASEL (0.61) | P2RY2P2RY1P2RX1P2RX3P2RX2 | |
| Adenosine Phosphate SCHEMBL6264787 | 0.87 | P2RY1 (0.73) | P2RY2P2RY1P2RX1P2RX3P2RX2 | |
| SCHEMBL29468919 | 0.87 | P2RY1 (0.80) | P2RY2P2RY1P2RX1P2RX3P2RX2 | |
| SCHEMBL13455400 | 0.86 | DTYMK (0.62) | P2RY2P2RY4P2RY6DTYMKP2RY1 | |
| Adenosine SCHEMBL3207685 | 0.86 | P2RY2 (0.70) | P2RY2P2RY4P2RY6DTYMKP2RY1 | |
| Deoxyadenosine SCHEMBL21001775 | 0.86 | DNMT1 (0.66) | SMN1; SMN2 | |
| SCHEMBL13421164 | 0.86 | P2RY1 (0.83) | P2RY2DTYMKP2RY1P2RX1P2RX3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7682809-B2 | Direct ATP release sequencing | AGILENT TECHNOLOGIES, INC. (US) | 2010-03-23 | — | — | US | claimed |
| US-20090181374-A1 | DIRECT ATP RELEASE SEQUENCING | AGILENT TECHNOLOGIES, INC. | 2009-07-16 | — | — | US | claimed |
| US-7682809-B2 | Direct ATP release sequencing | AGILENT TECHNOLOGIES, INC. (US) | 2010-03-23 | — | — | US | disclosed |
| US-20090181374-A1 | DIRECT ATP RELEASE SEQUENCING | AGILENT TECHNOLOGIES, INC. | 2009-07-16 | — | — | US | disclosed |