Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRB3 | P28472 | 20/20 | 0.42 |
| ▸ | GABRA2 | P47869 | 15/20 | 0.42 |
| ▸ | GABRB2 | P47870 | 15/20 | 0.42 |
| ▸ | GABRP | O00591 | 12/20 | 0.42 |
| ▸ | GABRD | O14764 | 12/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 12/20 | 0.42 |
| ▸ | GABRB1 | P18505 | 12/20 | 0.42 |
| ▸ | GABRG2 | P18507 | 12/20 | 0.42 |
| ▸ | GABRA5 | P31644 | 12/20 | 0.42 |
| ▸ | GABRA3 | P34903 | 12/20 | 0.42 |
| ▸ | GABRA4 | P48169 | 12/20 | 0.42 |
| ▸ | GABRE | P78334 | 12/20 | 0.42 |
| ▸ | GABRA6 | Q16445 | 12/20 | 0.42 |
| ▸ | GABRG1 | Q8N1C3 | 12/20 | 0.42 |
| ▸ | GABRG3 | Q99928 | 12/20 | 0.42 |
| ▸ | GABRQ | Q9UN88 | 12/20 | 0.42 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3202450 | 0.83 | GABRB3 (0.48) | GABRB3GABRA2GABRB2GABRPGABRD | |
| SCHEMBL3257450 | 0.81 | GABRB3 (0.43) | GABRB3GABRA2GABRB2GABRPGABRD | |
| SCHEMBL3189825 | 0.80 | GABRB3 (0.54) | GABRB3GABRA2GABRB2GABRPGABRD | |
| SCHEMBL7812275 | 0.77 | GABRB3 (0.55) | GABRB3GABRA2GABRB2GABRPGABRD | |
| SCHEMBL9704854 | 0.76 | GABRB3 (0.52) | GABRB3GABRA2GABRB2GABRPGABRD | |
| SCHEMBL9211808 | 0.75 | GABRB3 (0.48) | GABRB3GABRA2GABRB2GABRPGABRD | |
| SCHEMBL9705750 | 0.73 | GABRB3 (0.54) | GABRB3GABRA2GABRB2GABRPGABRD | |
| SCHEMBL9209787 | 0.73 | GABRB3 (0.54) | GABRB3GABRA2GABRB2GABRPGABRD | |
| SCHEMBL9704033 | 0.73 | GABRB3 (0.40) | GABRB3GABRA2GABRB2GABRPGABRD | |
| SCHEMBL9704055 | 0.72 | GABRB3 (0.42) | GABRB3GABRA2GABRB2GABRPGABRD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7678923-B2 | Method for synthesizing 5-chloro-1-aryl-4-(4,5-dicyano-1h-imidazol-2-yl)-3-alkyl-1h-pyrazole derivatives | EVULTIS (CH) | 2010-03-16 | — | — | US | disclosed |
| US-20070155811-A1 | Method for synthesing 5-chloro-1-aryl-4-(4,5-dicyano-1h-imidazol-2-yl)-3-alkyl-1h-pyrazole derivatives | EVULTIS (CH) | 2007-07-05 | — | — | US | disclosed |
| EP-1618104-B1 | METHOD FOR SYNTHESISING 5-CHLORO-1-ARYL-4-(4, 5-DICYANO-1H-IMIDAZOL-2-YL)-3-ALKYL-1H-PYRAZOLE DERIVATIVES | EVULTIS (CH) | 2007-06-20 | — | — | EP | disclosed |
| EP-1618104-A1 | METHOD FOR SYNTHESISING 5-CHLORO-1-ARYL-4-(4, 5-DICYANO-1H-IMIDAZOL-2-YL)-3-ALKYL-1H-PYRAZOLE DERIVATIVES | Evultis (CH) | 2006-01-25 | — | — | EP | disclosed |
| WO-2004092159-A1 | METHOD FOR SYNTHESISING 5-CHLORO-1-ARYL-4-(4, 5-DICYANO-1H-IMIDAZOL-2-YL)-3-ALKYL-1H-PYRAZOLE DERIVATIVES | EVULTIS (CH) | 2004-10-28 | — | — | WO | disclosed |
| EP-0412849-B1 | Azole pesticides | AGREVO UK LTD (GB) | 1995-12-20 | — | — | EP | disclosed |
| CN-1025582-C | Azole pesticides | SCHERING AGROCHEMICALS LTD (GB) | 1994-08-10 | — | — | CN | disclosed |
| US-5189053-A | Insecticide, acaricide and endoparasiticide | SCHERING AGROCHEMICALS LIMITED (GB) | 1993-02-23 | — | — | US | disclosed |
| US-5109012-A | 2-IMIDAZOL(IN)E SUBSTITUTED ARYL-1,2,3-TRIAZOLE PESTICIDES | SCHERING AGROCHEMICALS LIMITED (GB) | 1992-04-28 | — | — | US | disclosed |
| CN-1049341-A | AZOLE PESTICIDES | SCHERING AGROCHEMICALS LTD (GB) | 1991-02-20 | — | — | CN | disclosed |
| EP-0412849-A2 | Azole pesticides | AgrEvo UK Limited (GB) | 1991-02-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070155811-A1 | Method for synthesing 5-chloro-1-aryl-4-(4,5-dicyano-1h-imidazol-2-yl)-3-alkyl-1h-pyrazole derivatives | CYP3A5, CYP4B1, AADAC | GABRB3 1154/4885GABRA2 1786/4885GABRB2 1709/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.