Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 1/20 | 0.65 |
| ▸ | RXRB | P28702 | 1/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.63 |
| ▸ | NPC1 | O15118 | 5/20 | 0.63 |
| ▸ | RAB9A | P51151 | 5/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.63 |
| ▸ | MEN1 | O00255 | 4/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.60 |
| ▸ | CDC25A | P30304 | 2/20 | 0.59 |
| ▸ | CDC25B | P30305 | 2/20 | 0.59 |
| ▸ | CDC25C | P30307 | 2/20 | 0.59 |
| ▸ | DUSP3 | P51452 | 2/20 | 0.59 |
| ▸ | EIF4E | P06730 | 2/20 | 0.55 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.54 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.53 |
| ▸ | PDE4A | P27815 | 1/20 | 0.53 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.53 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.53 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7217226 | 0.86 | CDC25A (0.62) | KDM4ENPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL7222214 | 0.82 | KDM4E (0.70) | KDM4ENPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL6200825 | 0.81 | PDE4A (0.72) | KDM4ENPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL17336695 | 0.80 | SMN1; SMN2 (0.81) | KDM4ENPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL4758879 | 0.80 | RXRA (1.00) | RXRARXRBSMN1; SMN2KMT2AMAPK1 | |
| SCHEMBL18314425 | 0.80 | RXRA (1.00) | RXRARXRBSMN1; SMN2KMT2AMAPK1 | |
| SCHEMBL12797778 | 0.79 | CYP19A1 (0.69) | KDM4ENPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL7507983 | 0.79 | KDM4E (1.00) | KDM4ENPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL7221293 | 0.79 | KDM4E (1.00) | KDM4ENPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL7215184 | 0.78 | KDM4E (0.73) | KDM4ENPC1RAB9ASMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1784400-B1 | HISTAMINE H3 RECEPTOR AGENTS, PREPARATION AND THERAPEUTIC USES | LILLY CO ELI (US) | 2015-01-14 | — | — | EP | disclosed |
| US-7705025-B2 | Histamine H3 receptor agents, preparation and therapeutic uses | ELI LILLY AND COMPANY (US) | 2010-04-27 | — | — | US | disclosed |
| US-20100029608-A1 | Histamine H3 Receptor Agents, Preparation and Therapeutic Uses | FINLEY DON RICHARD | 2010-02-04 | — | — | US | disclosed |
| US-20090048225-A1 | HISTAMINE H3 RECEPTOR AGENTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY | 2009-02-19 | — | — | US | disclosed |
| EP-1784400-A1 | HISTAMINE H3 RECEPTOR AGENTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-05-16 | — | — | EP | disclosed |
| WO-2006023462-A1 | HISTAMINE H3 RECEPTOR AGENTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2006-03-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090048225-A1 | HISTAMINE H3 RECEPTOR AGENTS, PREPARATION AND THERAPEUTIC USES | HRH3, HRH4, HCRTR1 | RXRA 2283/4885RXRB 2128/4885KDM4E 487/4885 |
| US-20100029608-A1 | Histamine H3 Receptor Agents, Preparation and Therapeutic Uses | HRH3, HRH4, HCRTR1 | RXRA 2272/4885RXRB 2175/4885KDM4E 480/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.