Acetic Acid

Acetic Acid

SCHEMBL320014

CC(=O)O.CCC(N)(O)C(C)(CC)CC

nearest known ligand 0.37

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.34
MEN1 O00255 1/20 0.34
CYP1A2 P05177 1/20 0.34
THRB P10828 1/20 0.34
KMT2A Q03164 1/20 0.34
HMGCR P04035 1/20 0.33
CHRM1 P11229 1/20 0.33
TBXA2R P21731 1/20 0.33
ADRA1A P35348 1/20 0.33
TSHR P16473 1/20 0.33
FFAR3 O14843 1/20 0.33
LCK P06239 1/20 0.33
FYN P06241 1/20 0.33
GRM2 Q14416 1/20 0.31
GRM3 Q14832 1/20 0.31
GGT1 P19440 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2064680 0.87 TSHR (0.33) ALDH1A1TSHR
Water SCHEMBL319991 0.85 TSHR (0.32) TSHR
Acetic Acid SCHEMBL4621908 0.79 FFAR3 (0.41) ALDH1A1MEN1CYP1A2THRBKMT2A
Acetic Acid SCHEMBL10762669 0.76 FFAR3 (0.44) ALDH1A1MEN1CYP1A2THRBKMT2A
Acetic Acid SCHEMBL699536 0.76 FFAR3 (0.44) ALDH1A1MEN1CYP1A2THRBKMT2A
Acetic Acid SCHEMBL241364 0.76 FFAR3 (0.44) ALDH1A1MEN1CYP1A2THRBKMT2A
Acetic Acid SCHEMBL10949299 0.74 FFAR3 (0.41) ALDH1A1MEN1CYP1A2THRBKMT2A
Acetic Acid SCHEMBL11415706 0.74 FFAR3 (0.41) ALDH1A1MEN1CYP1A2THRBKMT2A
Acetic Acid SCHEMBL28664506 0.73 FFAR3 (0.47) ALDH1A1MEN1CYP1A2THRBKMT2A
Amylene Hydrate SCHEMBL6302374 0.73 FFAR3 (0.47) ALDH1A1MEN1CYP1A2THRBKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10717880-B2 Polyisocyanate-based anti-corrosion coating HUNTSMAN INTERNATIONAL LLC (US) 2020-07-21 US disclosed
US-10030094-B2 Polyisocyanurate-based syntactic coating for offshore applications HUNTSMAN INTERNATIONAL LLC (US) 2018-07-24 US disclosed
US-9926479-B2 Materials comprising a matrix and process for preparing them HUNTSMAN INTERNATIONAL LLC (US) 2018-03-27 US disclosed
US-9534072-B2 Polyisocyanate-based adhesive HUNTSMAN INTERNATIONAL LLC (US) 2017-01-03 US disclosed
EP-2300509-B1 A POLYISOCYANURATE-BASED SYNTACTIC COATING FOR OFFSHORE APPLICATIONS HUNTSMAN INT LLC (US) 2016-08-10 EP disclosed
EP-2245081-B1 ELASTOMERIC MATERIALS HAVING A HIGH HARDBLOCK CONTENT AND PROCESS FOR PREPARING THEM HUNTSMAN INT LLC (US) 2015-09-16 EP disclosed
US-20150125704-A1 Polyisocyanate-Based Anti-Corrosion Coating HUNTSMAN INTERNATIONAL LLC 2015-05-07 US disclosed
US-8962142-B2 Polyisocyanate-based anti-corrosion coating HUNTSMAN INTERNATIONAL LLC (US) 2015-02-24 US disclosed
US-8519062-B2 Elastomeric materials having a high hardblock content and process for preparing them HUNTSMAN INTERNATIONAL LLC (US) 2013-08-27 US disclosed
EP-2591029-A1 POLYISOCYANATE-BASED ANTI-CORROSION COATING Huntsman International LLC (US) 2013-05-15 EP disclosed
WO-2009101027-A1 ELASTOMERIC MATERIALS HAVING A HIGH HARDBLOCK CONTENT AND PROCESS FOR PREPARING THEM HUNTSMAN INTERNATIONAL LLC (US) 2009-08-20 WO disclosed
WO-2008110604-A1 POLYISOCYANATE-BASED ADHESIVE HUNTSMAN INTERNATIONAL LLC (US) 2008-09-18 WO disclosed
WO-2008110602-A1 POLYISOCYANATE-BASED ADHESIVE HUNTSMAN INTERNATIONAL LLC (US) 2008-09-18 WO disclosed
WO-2008110605-A1 POLYISOCYANATE-BASED ADHESIVE HUNTSMAN INTERNATIONAL LLC (US) 2008-09-18 WO disclosed
EP-1970420-A1 Polyisocyanate-based adhesive composition HUNTSMAN INTERNATIONAL LLC (US) 2008-09-17 EP disclosed
US-7405258-B2 Method for producing polyurethane emulsion for aqueous one-component coating agent NIPPON POLYURETHANE INDUSTRY CO., LTD. (JP) 2008-07-29 US disclosed
US-20070155894-A1 Method for producing polyurethane emulsion for aqueous one-component coating agent NIPPON POLYURETHANE INDUSTRY CO., LTD. 2007-07-05 US disclosed
EP-1721947-A1 PROCESS FOR PRODUCING POLYURETHANE EMULSION FOR WATER-BASED ONE-PACK TYPE COATING MATERIAL Nippon Polyurethane Industry Co., Ltd. (JP) 2006-11-15 EP disclosed
US-6596819-B2 An isocyanate group-terminated prepolymer having isocyanurate group and urethane group, obtained by reacting an organic polyisocyanate containing at least (a1) an aromatic diisocyanate with an active hydrogen group-containing compound NIPPON POLYURETHANE INDUSTRY CO., LTD. (JP) 2003-07-22 US disclosed
US-20030083451-A1 Polyisocyanate curing agent for laminate adhesive and process for production thereof NIPPON POLYURETHANE INDUSTRY CO., LTD. (JP) 2003-05-01 US disclosed