Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 4/20 | 0.38 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.34 |
| ▸ | PDE4A | P27815 | 3/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.34 |
| ▸ | RXRA | P19793 | 2/20 | 0.33 |
| ▸ | RXRB | P28702 | 1/20 | 0.32 |
| ▸ | RXRG | P48443 | 1/20 | 0.32 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3195028 | 0.96 | PDE4B (0.38) | PDE4BSLC7A5PDE4DPDE4APDE4C | |
| SCHEMBL3126325 | 0.92 | RXRA (0.38) | PDE4BPDE4DPDE4APDE4CRXRA | |
| SCHEMBL3126155 | 0.92 | GRM2 (0.43) | PDE4BSLC7A5PDE4DPDE4APDE4C | |
| SCHEMBL3217020 | 0.91 | SLC7A5 (0.37) | PDE4BSLC7A5GRM2RXRARXRB | |
| SCHEMBL3122587 | 0.89 | RXRA (0.36) | PDE4BSLC7A5PDE4DPDE4APDE4C | |
| SCHEMBL3128958 | 0.89 | GRM2 (0.37) | PDE4BGRM2MAPT | |
| SCHEMBL3117619 | 0.88 | RXRA (0.41) | PDE4BPDE4DPDE4APDE4CGRM2 | |
| SCHEMBL3120270 | 0.88 | PDE4A (0.38) | PDE4BPDE4DPDE4APDE4CRXRA | |
| SCHEMBL4196553 | 0.88 | GRM2 (0.40) | PDE4BSLC7A5PDE4DPDE4APDE4C | |
| SCHEMBL3199477 | 0.87 | AAK1 (0.33) | PDE4BSLC7A5PDE4DPDE4APDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100029689-A1 | PHOSPHODIESTERASE 4 INHIBITORS | MEMORY PHARMACEUTICALS CORPORATION (US) | 2010-02-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029689-A1 | PHOSPHODIESTERASE 4 INHIBITORS | PDE4A, PDE4B, PDE3B | PDE4B 2/4885SLC7A5 3593/4885PDE4D 9/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.