⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6049109 | 0.96 | MEN1 (0.92) | — | |
| Morpholine SCHEMBL922866 | 0.96 | — | — | |
| Morpholine SCHEMBL18577399 | 0.96 | — | — | |
| Morpholine SCHEMBL986 | 0.96 | — | — | |
| SCHEMBL244992 | 0.96 | MEN1 (0.92) | — | |
| Morpholine SCHEMBL7996463 | 0.96 | MEN1 (0.92) | — | |
| Morpholine SCHEMBL3233209 | 0.96 | MEN1 (0.92) | — | |
| Morpholine SCHEMBL18434 | 0.96 | — | — | |
| SCHEMBL22491036 | 0.96 | MEN1 (0.92) | — | |
| Morpholine SCHEMBL28529603 | 0.96 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 53 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12577254-B2 | Thienopyranones and furanopyranones as kinase, bromodomain, and checkpoint inhibitors | Signal Rx Pharmaceuticals, Inc. | 2026-03-17 | — | — | US | disclosed |
| EP-3947351-B1 | SMALL MOLECULE PARG INHIBITORS AND METHODS OF USE THEREOF | UNIV TEXAS (US) | 2026-03-11 | — | — | EP | disclosed |
| US-12491188-B2 | Small molecule PARG inhibitors and methods of use thereof | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2025-12-09 | — | — | US | disclosed |
| US-12291502-B2 | Topoisomerase II-alpha inhibitors and methods of treating cancer using the same | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (US) | 2025-05-06 | — | — | US | disclosed |
| WO-2025024400-A2 | SUBSTITUTED TRYPTAMINES AND USES THEREOF | 2A BIOSCIENCES, INC. (US) | 2025-01-30 | — | — | WO | disclosed |
| EP-4466366-A2 | REAGENTS AND SYSTEMS FOR GENERATING BIOSENSORS | The Regents of the University of California (US) | 2024-11-27 | — | — | EP | disclosed |
| WO-2024178425-A1 | HYDROXYALKYL AND METHOXYALKYL TRYPTAMINES | 2A BIOSCIENCES, INC. (US) | 2024-08-29 | — | — | WO | disclosed |
| US-20240241099-A1 | METHOD FOR IDENTIFYING PI3 KINASE-ALPHA INHIBITORS | UNIVERSITÄT BASEL (CH) | 2024-07-18 | — | — | US | disclosed |
| US-20240150333-A1 | TAF1 INHIBITORS | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. | 2024-05-09 | — | — | US | disclosed |
| US-20240109892-A1 | POLY(ADP-RIBOSE) GLYCOHYDROLASE (PARG) INHIBITORS AGAINST COVID MACRODOMAIN AND METHODS OF USING THE SAME | NATIONAL INSTITUTES OF HEALTH | 2024-04-04 | — | — | US | disclosed |
| EP-2744330-A1 | SUBSTITUTED (E)-N'-(1-PHENYLETHYLIDENE) BENZOHYDRAZIDE ANALOGS AS HISTONE DEMETHYLASE INHIITORS | University Of Utah Research Foundation (US) | 2014-06-25 | — | — | EP | disclosed |
| US-20140163017-A1 | SUBSTITUTED (E)-N'-(1-PHENYLETHYLIDENE)BENZOHYDRAZIDE ANALOGS AS HISTONE DEMETHYLASE INHIBITORS | UNIVERSITY OF UTAH (US) | 2014-06-12 | — | — | US | disclosed |
| WO-2013025805-A1 | SUBSTITUTED (E)-N'-(1-PHENYLETHYLIDENE) BENZOHYDRAZIDE ANALOGS AS HISTONE DEMETHYLASE INHIITORS | UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) | 2013-02-21 | — | — | WO | disclosed |
| US-7666646-B2 | Crystal structure of human Pim-1 kinase protein complexes and binding pockets thereof, and uses thereof in drug design | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-02-23 | — | — | US | disclosed |
| US-20070031956-A1 | Crystal structure of human PIM-1 kinase protein complexes and binding pockets thereof, and uses thereof in drug design | VERTEX PHARMACEUTICALS INCORPORATED | 2007-02-08 | — | — | US | disclosed |
| US-6934639-B1 | Methods for designing agents that interact with MMP-13 | WYETH (US) | 2005-08-23 | — | — | US | disclosed |
| EP-1274980-A4 | SOLUTION AND CRYSTAL STRUCTURES OF MMP-13 ACTIVE SITE AND USES THEREOF | WYETH CORP (US) | 2005-02-09 | — | — | EP | disclosed |
| CN-1423748-A | Solutions and crystal structures of MMP-13 active site and uses thereof | WYETH CORP (US) | 2003-06-11 | — | — | CN | disclosed |
| EP-1274980-A1 | SOLUTION AND CRYSTAL STRUCTURES OF MMP-13 ACTIVE SITE AND USES THEREOF | Wyeth (US) | 2003-01-15 | — | — | EP | disclosed |
| WO-2001063244-A1 | SOLUTION AND CRYSTAL STRUCTURES OF MMP-13 ACTIVE SITE AND USES THEREOF | WYETH (US) | 2001-08-30 | — | — | WO | disclosed |