Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.35 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.35 |
| ▸ | CIT | O14578 | 1/20 | 0.35 |
| ▸ | GAK | O14976 | 1/20 | 0.35 |
| ▸ | PRKX | P51817 | 1/20 | 0.35 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.35 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.35 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.35 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.35 |
| ▸ | BMP2K | Q9NSY1 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 10/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3219020 | 0.96 | RXRA (0.36) | HDAC6PDE4DAAK1CITGAK | |
| SCHEMBL3193658 | 0.95 | POLB (0.40) | HDAC6PDE4DAAK1CITGAK | |
| SCHEMBL3126123 | 0.94 | HRH4 (0.38) | HDAC6PDE4DAAK1CITGAK | |
| SCHEMBL3214566 | 0.91 | PDE4D (0.43) | PDE4DPDE4APDE4BPDE4CGPR119 | |
| SCHEMBL3213999 | 0.90 | PDE4B (0.45) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL3199477 | 0.89 | AAK1 (0.33) | HDAC6PDE4DAAK1CITGAK | |
| SCHEMBL3207092 | 0.88 | POLB (0.39) | PDE4DAAK1CITGAKPRKX | |
| SCHEMBL3192278 | 0.87 | AAK1 (0.39) | HDAC6PDE4DAAK1PDE4APDE4B | |
| SCHEMBL3194660 | 0.86 | PDE4A (0.40) | PDE4DAAK1CITGAKPRKX | |
| SCHEMBL3130978 | 0.86 | HRH4 (0.36) | HDAC6PDE4DAAK1CITGAK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100029689-A1 | PHOSPHODIESTERASE 4 INHIBITORS | MEMORY PHARMACEUTICALS CORPORATION (US) | 2010-02-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029689-A1 | PHOSPHODIESTERASE 4 INHIBITORS | PDE4A, PDE4B, PDE3B | HDAC6 329/4885PDE4D 9/4885AAK1 2805/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.