Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 16/20 | 0.81 |
| ▸ | GSK3B | P49841 | 2/20 | 0.49 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL320400 | 1.00 | ROCK2 (0.81) | ROCK2GSK3BCSNK2A1KDM4E | |
| SCHEMBL10277446 | 0.91 | ROCK2 (0.75) | ROCK2KDM4E | |
| SCHEMBL10277445 | 0.91 | ROCK2 (0.75) | ROCK2KDM4E | |
| SCHEMBL321408 | 0.90 | ROCK2 (0.76) | ROCK2KDM4E | |
| SCHEMBL321409 | 0.90 | ROCK2 (0.76) | ROCK2KDM4E | |
| SCHEMBL321005 | 0.89 | ROCK2 (1.00) | ROCK2 | |
| SCHEMBL321004 | 0.89 | ROCK2 (1.00) | ROCK2 | |
| SCHEMBL10070379 | 0.89 | ROCK2 (1.00) | ROCK2 | |
| SCHEMBL320300 | 0.88 | ROCK2 (0.75) | ROCK2KDM4E | |
| SCHEMBL320301 | 0.88 | ROCK2 (0.75) | ROCK2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2590942-A1 | RHO KINASE INHIBITORS | Boehringer Ingelheim International GmbH (DE) | 2013-05-15 | — | — | EP | disclosed |
| WO-2012006202-A1 | RHO KINASE INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-01-12 | — | — | WO | disclosed |