Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.76 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.71 |
| ▸ | MAPT | P10636 | 5/20 | 0.69 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.69 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.69 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.66 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.66 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5006050 | 0.90 | ALDH1A1 (0.67) | ALDH1A1KMT2AMAPTNPSR1MAPK1 | |
| SCHEMBL11828208 | 0.84 | ALDH1A1 (0.79) | ALDH1A1KMT2AMAPTNPSR1MAPK1 | |
| SCHEMBL2628838 | 0.81 | MAPT (1.00) | ALDH1A1KMT2AMAPTNPSR1MAPK1 | |
| SCHEMBL10504252 | 0.77 | ALDH1A1 (0.53) | ALDH1A1KMT2AMAPTNPSR1MAPK1 | |
| SCHEMBL971969 | 0.77 | ALDH1A1 (0.59) | ALDH1A1KMT2AMAPTNPSR1MAPK1 | |
| SCHEMBL3719362 | 0.77 | ALDH1A1 (0.67) | ALDH1A1KMT2AMAPTNPSR1MAPK1 | |
| SCHEMBL1123936 | 0.77 | ALDH1A1 (0.63) | ALDH1A1KMT2AMAPTNPSR1MAPK1 | |
| SCHEMBL26337500 | 0.76 | ALDH1A1 (0.59) | ALDH1A1KMT2AMAPTNPSR1MAPK1 | |
| SCHEMBL5008170 | 0.75 | ALDH1A1 (0.51) | ALDH1A1KMT2AMAPTNPSR1MAPK1 | |
| SCHEMBL1707833 | 0.73 | ALDH1A1 (0.56) | ALDH1A1KMT2AMAPTNPSR1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100137311-A1 | SUBSTITUTED PYRIMIDINE DERIVATIVES | H. LUNDBECK A/S (DK) | 2010-06-03 | — | — | US | disclosed |
| US-20100137311-A1 | SUBSTITUTED PYRIMIDINE DERIVATIVES | H. LUNDBECK A/S (DK) | 2010-06-03 | — | — | US | disclosed |
| US-7683058-B2 | Substituted pyrimidine derivatives | H. LUNDBECK A/S (DK) | 2010-03-23 | — | — | US | disclosed |
| US-7683058-B2 | Substituted pyrimidine derivatives | H. LUNDBECK A/S (DK) | 2010-03-23 | — | — | US | disclosed |
| CN-101258133-A | Pyrimidine derivatives and their use as kcnq potassium channels openers | LUNDBECK & CO AS H (DK) | 2008-09-03 | — | — | CN | disclosed |
| EP-1937653-A1 | PYRIMIDINE DERIVATIVES AND THEIR USE AS KCNQ POTASSIUM CHANNELS OPENERS | H.Lundbeck A/S (DK) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007065449-A1 | PYRIMIDINE DERIVATIVES AND THEIR USE AS KCNQ POTASSIUM CHANNELS OPENERS | H. LUNDBECK A/S (DK) | 2007-06-14 | — | — | WO | disclosed |
| WO-2007065449-A1 | PYRIMIDINE DERIVATIVES AND THEIR USE AS KCNQ POTASSIUM CHANNELS OPENERS | H. LUNDBECK A/S (DK) | 2007-06-14 | — | — | WO | disclosed |
| US-20070066612-A1 | Substituted pyrimidine derivatives | H. LUNDBECK A/S (DK) | 2007-03-22 | — | — | US | disclosed |
| US-20070066612-A1 | Substituted pyrimidine derivatives | H. LUNDBECK A/S (DK) | 2007-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070066612-A1 | Substituted pyrimidine derivatives | DPYD, TYMP, TYMS | ALDH1A1 641/4885KMT2A 3194/4885MAPT 3682/4885 |
| US-20100137311-A1 | SUBSTITUTED PYRIMIDINE DERIVATIVES | DPYD, TYMP, TYMS | ALDH1A1 641/4885KMT2A 3194/4885MAPT 3682/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.