Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | SREBF1 | P36956 | 1/20 | 0.40 |
| ▸ | QPCT | Q16769 | 3/20 | 0.40 |
| ▸ | PDE4A | P27815 | 2/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3129630 | 0.93 | MAPT (0.44) | NPC1MAPTALDH1A1USP2NPSR1 | |
| SCHEMBL3125310 | 0.88 | GRM2 (0.40) | MAPTGRM2ALDH1A1PDE4APDE4B | |
| SCHEMBL3129016 | 0.88 | TSHR (0.50) | NPC1MAPTGRM2ALDH1A1USP2 | |
| SCHEMBL3122799 | 0.88 | PDE4B (0.42) | MAPTGRM2ALDH1A1USP2NPSR1 | |
| SCHEMBL3128958 | 0.88 | GRM2 (0.37) | NPC1MAPTGRM2ALDH1A1ALOX15 | |
| SCHEMBL2910936 | 0.87 | PDK1 (0.41) | MAPTGRM2L3MBTL1QPCTPDK1 | |
| SCHEMBL2908090 | 0.87 | PDK1 (0.42) | GRM2ALDH1A1USP2NPSR1L3MBTL1 | |
| SCHEMBL2908204 | 0.86 | MKNK1 (0.48) | GRM2ALDH1A1USP2NPSR1L3MBTL1 | |
| SCHEMBL3126048 | 0.85 | SREBF1 (0.41) | NPC1MAPTALDH1A1L3MBTL1HSD17B10 | |
| SCHEMBL3129701 | 0.85 | SREBF1 (0.40) | NPC1MAPTALDH1A1NPSR1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100029689-A1 | PHOSPHODIESTERASE 4 INHIBITORS | MEMORY PHARMACEUTICALS CORPORATION (US) | 2010-02-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029689-A1 | PHOSPHODIESTERASE 4 INHIBITORS | PDE4A, PDE4B, PDE3B | NPC1 3803/4885MAPT 4197/4885GRM2 3498/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.