Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 3/20 | 0.51 |
| ▸ | MELK | Q14680 | 1/20 | 0.46 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 9/20 | 0.44 |
| ▸ | GSK3B | P49841 | 6/20 | 0.44 |
| ▸ | WNT1 | P04628 | 2/20 | 0.44 |
| ▸ | BRAF | P15056 | 2/20 | 0.43 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.42 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.42 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.42 |
| ▸ | MAP4K3 | Q8IVH8 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | CLK2 | P49760 | 1/20 | 0.41 |
| ▸ | CLK3 | P49761 | 1/20 | 0.41 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30576672 | 0.81 | PIK3CD (0.47) | MELKDYRK1AMAP4K3MKNK1 | |
| SCHEMBL320961 | 0.79 | MET (0.47) | METNTRK1DYRK1AGSK3BWNT1 | |
| SCHEMBL10153117 | 0.78 | NTRK1 (0.51) | METNTRK1DYRK1AGSK3BWNT1 | |
| SCHEMBL31276806 | 0.78 | DYRK1A (0.47) | METNTRK1DYRK1AGSK3BWNT1 | |
| SCHEMBL31669134 | 0.78 | MKNK1 (0.51) | METDYRK1AGSK3BWNT1CLK2 | |
| SCHEMBL319690 | 0.77 | MET (0.52) | METNTRK1DYRK1AGSK3BWNT1 | |
| Hydrochloric Acid SCHEMBL320673 | 0.77 | NTRK1 (0.51) | METNTRK1DYRK1AGSK3BWNT1 | |
| SCHEMBL320680 | 0.75 | MET (0.46) | METNTRK1DYRK1AGSK3BWNT1 | |
| SCHEMBL2364303 | 0.74 | MET (0.41) | METNTRK1DYRK1AGSK3BWNT1 | |
| SCHEMBL17303134 | 0.72 | MET (0.42) | METNTRK1MAP4K3MKNK1MKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2590946-A1 | BIPYRIDYL DERIVATIVES USEFUL FOR THE TREATMENT OF KINASE - INDUCED DISEASES | Merck Patent GmbH (DE) | 2013-05-15 | — | — | EP | disclosed |
| WO-2012003912-A1 | BIPYRIDYL DERIVATIVES USEFUL FOR THE TREATMENT OF KINASE - INDUCED DISEASES | MERCK PATENT GMBH (DE) | 2012-01-12 | — | — | WO | disclosed |