Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 4/20 | 0.67 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.67 |
| ▸ | BACE1 | P56817 | 8/20 | 0.63 |
| ▸ | APP | P05067 | 5/20 | 0.63 |
| ▸ | MAPT | P10636 | 4/20 | 0.63 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.56 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | GSK3B | P49841 | 2/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | PTGES | O14684 | 1/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.53 |
| ▸ | CA12 | O43570 | 1/20 | 0.53 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.53 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3207731 | 1.00 | NFE2L2 (0.67) | NFE2L2ABCG2BACE1APPMAPT | |
| SCHEMBL22605243 | 0.89 | ABCG2 (0.63) | NFE2L2ABCG2BACE1APPMAPT | |
| SCHEMBL3211619 | 0.88 | BACE1 (0.74) | NFE2L2ABCG2BACE1APPMAPT | |
| SCHEMBL3211604 | 0.88 | BACE1 (0.74) | NFE2L2ABCG2BACE1APPMAPT | |
| SCHEMBL7954649 | 0.85 | ABCG2 (0.67) | NFE2L2ABCG2BACE1APPMAPT | |
| SCHEMBL6776974 | 0.85 | ABCG2 (0.67) | NFE2L2ABCG2BACE1APPMAPT | |
| SCHEMBL6776970 | 0.85 | ABCG2 (0.67) | NFE2L2ABCG2BACE1APPMAPT | |
| SCHEMBL3567982 | 0.85 | ABCG2 (0.71) | NFE2L2ABCG2MAPTCYP2D6CYP1A2 | |
| SCHEMBL3567978 | 0.85 | ABCG2 (0.71) | NFE2L2ABCG2MAPTCYP2D6CYP1A2 | |
| SCHEMBL3222949 | 0.84 | APP (0.90) | NFE2L2ABCG2BACE1APPMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8962674-B2 | Curcumin derivative | TOKYO INSTITUTE OF TECHNOLOGY (JP) | 2015-02-24 | — | — | US | disclosed |
| US-20100048901-A1 | NOVEL CURCUMIN DERIVATIVE | TOKYO INSTITUTE OF TECHNOLOGY (JP) | 2010-02-25 | — | — | US | disclosed |
| EP-2123637-A1 | NOVEL CURCUMIN DERIVATIVE | Tokyo Institute of Technology (JP) | 2009-11-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100048901-A1 | NOVEL CURCUMIN DERIVATIVE | BACE1, APP, BACE2 | NFE2L2 309/4885ABCG2 3722/4885BACE1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.