⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL905827 | 0.91 | — | — | |
| SCHEMBL8029168 | 0.84 | NAAA (0.35) | — | |
| SCHEMBL8036426 | 0.81 | MIF (0.52) | — | |
| SCHEMBL1507224 | 0.81 | MIF (0.52) | — | |
| SCHEMBL5458365 | 0.81 | MIF (0.52) | — | |
| SCHEMBL5465520 | 0.81 | MIF (0.52) | — | |
| SCHEMBL8312134 | 0.81 | MIF (0.52) | — | |
| SCHEMBL6595202 | 0.80 | MEN1 (0.63) | — | |
| SCHEMBL9036474 | 0.80 | — | — | |
| SCHEMBL9037335 | 0.80 | MEN1 (0.63) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8324257-B2 | Mitotic kinesin inhibitors and methods of use thereof | ARRAY BIOPHARMA INC. (US) | 2012-12-04 | — | — | US | claimed |
| US-20100041719-A1 | MITOTIC KINESIN INHIBITORS AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC. (US) | 2010-02-18 | — | — | US | claimed |
| CN-101553476-A | Mitotic kinesin inhibitors and methods of use thereof | ARRAY BIOPHARMA INC (US) | 2009-10-07 | — | — | CN | claimed |
| US-8324257-B2 | Mitotic kinesin inhibitors and methods of use thereof | ARRAY BIOPHARMA INC. (US) | 2012-12-04 | — | — | US | disclosed |
| US-20100041719-A1 | MITOTIC KINESIN INHIBITORS AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC. (US) | 2010-02-18 | — | — | US | disclosed |
| CN-101553476-A | Mitotic kinesin inhibitors and methods of use thereof | ARRAY BIOPHARMA INC (US) | 2009-10-07 | — | — | CN | disclosed |
| EP-1829876-A1 | NITROGENEOUS TRICYCLIC COMPOUND | Asahi Kasei Pharma Corporation (JP) | 2007-09-05 | — | — | EP | disclosed |
| US-20060247266-A1 | Nitrogen-containing tricyclic compounds | ASAHI KASEI PHARMA CORPORATION (JP) | 2006-11-02 | — | — | US | disclosed |
| US-7105520-B2 | Phenylalanine derivatives | AJINOMOTO CO., INC. (JP) | 2006-09-12 | — | — | US | disclosed |
| US-20030130320-A1 | Phenylalanine derivatives | AJINOMOTO CO. INC (JP) | 2003-07-10 | — | — | US | disclosed |
| EP-1270547-A1 | NOVEL PHENYLALANINE DERIVATIVE | Ajinomoto Co., Inc. (JP) | 2003-01-02 | — | — | EP | disclosed |