⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methacrylic Acid SCHEMBL3292794 | 0.85 | FAAH (0.42) | — | |
| Acrylic Acid SCHEMBL3293229 | 0.85 | FAAH (0.42) | — | |
| SCHEMBL7444824 | 0.85 | — | — | |
| SCHEMBL23733193 | 0.83 | FAAH (0.48) | — | |
| SCHEMBL5768333 | 0.83 | FAAH (0.65) | — | |
| SCHEMBL5909462 | 0.83 | FAAH (0.64) | — | |
| Hydrochloric Acid SCHEMBL4300494 | 0.82 | FAAH (0.48) | — | |
| SCHEMBL2968023 | 0.81 | FAAH (0.69) | — | |
| SCHEMBL13614819 | 0.81 | FAAH (0.69) | — | |
| SCHEMBL2032986 | 0.81 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 63 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0355331-A2 | Poly(aminoalkyl)aminocarbonyl aminoacyl aminodiol amino acid derivatives as anti-hypertensive agents | G.D. Searle & Co. (US) | 1990-02-28 | — | — | EP | claimed |
| US-11649214-B2 | Inhibitors of the notch transcriptional activation complex kinase (“NACK”) and methods for use of the same | UNIVERSITY OF MIAMI (US) | 2023-05-16 | — | — | US | disclosed |
| EP-3900742-A1 | TARGETED DELIVERY OF TERTIARY AMINE-CONTAINING DRUG SUBSTANCES | Seagen Inc. (US) | 2021-10-27 | — | — | EP | disclosed |
| CN-109476841-B | Novel polymer derivative and novel polymer derivative imaging probe using same | 日本化药株式会社 | 2021-08-24 | — | — | CN | disclosed |
| CN-113195619-A | Polyethylene composition with improved environmental stress crack resistance | SABIC环球技术有限责任公司 | 2021-07-30 | — | — | CN | disclosed |
| US-20210171469-A1 | INHIBITORS OF THE NOTCH TRANSCRIPTIONAL ACTIVATION COMPLEX KINASE (\"NACK\") AND METHODS FOR USE OF THE SAME | UNIVERSITY OF MIAMI | 2021-06-10 | — | — | US | disclosed |
| CN-107249589-B | Physiologically active substance-binding block copolymer | 日本化药株式会社 | 2021-06-08 | — | — | CN | disclosed |
| US-10973762-B2 | Active-targeting-type polymer derivative, composition containing said polymer derivative, and uses of said polymer derivative and said composition | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 2021-04-13 | — | — | US | disclosed |
| CN-112313277-A | Polyethylene with polycarbonate-siloxane for improved environmental stress crack resistance | SABIC环球技术有限责任公司 | 2021-02-02 | — | — | CN | disclosed |
| CN-112154181-A | Polyethylene compositions having improved environmental stress crack resistance and methods of use | SABIC环球技术有限责任公司 | 2020-12-29 | — | — | CN | disclosed |
| EP-1064253-B1 | ANTI-TUMOUR AGENTS | ASTRAZENECA AB (SE) | 2003-01-29 | — | — | EP | disclosed |
| US-6346633-B1 | TERT-AMINOPHENYLESTER OF ACID | ASTRAZENECA AB (SE) | 2002-02-12 | — | — | US | disclosed |
| EP-1064253-A1 | ANTI-TUMOUR AGENTS | AstraZeneca AB (SE) | 2001-01-03 | — | — | EP | disclosed |
| WO-1999048857-A1 | ANTI-TUMOUR AGENTS | ASTRAZENECA AB (SE) | 1999-09-30 | — | — | WO | disclosed |
| US-5616582-A | Use as anticancer agents; e.g. gefitinib | ZENECA LIMITED (GB) | 1997-04-01 | — | — | US | disclosed |
| US-5602127-A | ADMINISTERING TO TREAT HYPERTENSION | KARL THOMAE GMBH (DE) | 1997-02-11 | — | — | US | disclosed |
| US-5594003-A | HYPOTENSIVE AGENTS | DR. KARL THOMAE GMBH (DE) | 1997-01-14 | — | — | US | disclosed |
| US-5457105-A | anticancer use; e.g. 4-(3'-chloro-4'-fluoroanilino)-6,7-dimethoxyquinazoline (gefitinib) | ZENECA LIMITED (GB) | 1995-10-10 | — | — | US | disclosed |
| EP-0566226-A1 | Quinazoline derivatives | ZENECA LIMITED (GB) | 1993-10-20 | — | — | EP | disclosed |
| EP-0355331-A2 | Poly(aminoalkyl)aminocarbonyl aminoacyl aminodiol amino acid derivatives as anti-hypertensive agents | G.D. Searle & Co. (US) | 1990-02-28 | — | — | EP | disclosed |